摘要
力学响应microRNA(miRNA)是一类对力学载荷敏感或者能产生响应的miRNA,在施加力学载荷以后,其表达量发生变化,并影响所调控的mRNA、蛋白质表达水平。迄今为止,已经在一些生理、病理组织或者器官中发现力学响应miRNA。然而,这些发现普遍具有局限性,尚不能很好地指导临床实践。基于此,本文对近几年力学响应miRNA的研究成果予以总结,以期为临床应用、后续研究提供指南。
Mechanoresponsive microRNAs are a type of miRNAs which are sensitive or responsive to mechanical strain applied to them, their expression levels were changed after mechanical loading, thus affecting the expression levels of mRNA and proteins they regulated. Up to now, some mechanoresponsive miRNAs have been discovered in physiological or pathological tissues or organs. However, these discoveries are usually limited, and they are not able to guide clinical practice well. According to this situation, this paper summarizes research findings of mechanoresponsive miRNAs, and provides directions for clinical practice and further researches.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2016年第3期583-586,共4页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目(11372351
11432016)
关键词
MIRNA
力学载荷
力学响应
临床应用
miRNA
mechanical stimulation
mechanoresponsive
clinical practice
