摘要
采用大鼠外翻肠囊模型,研究扶正消症方中小檗碱、巴马汀、黄连碱、表小檗碱4种黄连碱在大鼠不同肠段的吸收情况,计算各成分的吸收参数,用SPSS 20.0统计学软件对数据进行分析处理,分析其在不同肠段的吸收特征。结果显示,各生物碱成分在不同肠段的吸收均符合零级吸收速率;4种生物碱成分在低剂量时的吸收速率常数(Ka)与中、高剂量比较有显著性差异(P<0.05),但是中剂量与高剂量比较Ka并没有明显差异。扶正消症方提取物不同剂量时,4个生物碱在不同肠段的吸收方式除被动扩散外还存在主动转运。4个生物碱在回肠中的吸收量略高于空肠,但无显著性差异,表明这4个生物碱在小肠无特定吸收窗。
Everted intestinal sac models were used to investigate the intestinal absorption of the 4 alkaloids（berberine, paimatine, coptisine, and epiberberine） in Fuzheng Xiaozheng Fang（FZ） at different intestine segments. The absorption parameters of each component were calculated ; SPSS 20.0 software was used to analyze the data and evaluate the absorption characteristics at different intestinal segments. The resuhs showed that all the four active ingredients conformed to zero-order absorption rate. There was significant difference in absorption rate constant （Ka） between the four ingredients at low dose and medium and high dose groups（ P 〈 0. 05 ）, but there was no significant difference in Ka between medium dose and high dose. The absorption mechanization of four ingredients presented two absorption manners： positive diffusion and passive absorption. The absorptive amount of 4 alkaloids in ileum was slightly greater than that of jejunum, but no significant differences were observed, which indicated that these four alkaloids had no specific absorption windows in intestinal segment.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2016年第11期2144-2148,共5页
China Journal of Chinese Materia Medica
基金
国家"重大新药创制"科技重大专项(2012ZX09103201-027
2012ZX09103201-009)
中国中医科学院客座研究员联合创新研究项目(ZZ070837)
关键词
扶正消症方
小檗碱
巴马汀
黄连碱
表小檗碱
肠外翻
Fuzheng Xiaozheng Fang
berberine
palmatine
coptisine
epiberberine
everted intestinal sac
