摘要
目的探讨b型流感嗜血菌（Hib）感染以及其疫苗的安全性,为临床有效预防Hib感染提供依据。方法选择2014年1月-2015年1月于医院进行Hib疫苗接种的902名婴幼儿为研究对象,按年龄将婴幼儿分为12~59月龄组以及6~11月龄组,分析两组婴幼儿接种同种疫苗后的不良反应发生率。结果 902名婴幼儿接种同种疫苗后90例发生不良反应,发生率为9.98%,其中局部反应56例占62.22%,全身反应34例占37.78%;局部不良反应发生率6~11月龄组婴幼儿为7.68%,高于12~59月龄组婴幼儿的1.78%,差异有统计学意义（P〈0.05）;全身不良反应发生率6~11月龄组婴幼儿为3.84%,与12~59月龄组婴幼儿的3.56%,差异无统计学意义。结论 Hib结合疫苗应用在6月龄~5岁的小儿中安全性较好,但在对机体进行接种时应对小儿发生的全身以及局部不良反应进行密切关注,及时采取相应的措施进行处理。
OBJECTIVE To investigate the Haemophilus influenza type b（Hib）infection as well as its vaccine safety,so as to provide basis for the clinical prevention of HINb.METHODS A total of 902 infants vaccinated with Hib vaccine in the hospital from Jan.2014 to Jan.2015 were selected,and divided into 12-59 month group and 6-11 month group according to the age.The incidence of adverse reactions of the two groups of infants was analyzed.RESULTS Totally 90 cases of adverse reactions occurred in 902 infants,with the adverse reaction rate of9.98%,including local response of 56cases（62.22%）and systemic response of 34cases（37.78%）.The local adverse reaction rate of 6-11 month group was 7.68%,significantly higher than 0.89% of 12-59 month group（P〈0.05）.The systemic adverse reaction rate of 6-11 month group was 3.84%,and 3.56% of 12-59 month group,with no significant difference.CONCLUSION Hib conjugate vaccine applied in 6-month to 5-year-old children is safety,but it should pay close attention to systemic adverse reactions and local adverse reactions,and take appropriate measures to deal with the adverse reactions.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第12期2667-2668,2672,共3页
Chinese Journal of Nosocomiology
基金
山东省中青年自然科学基金资助项目(2014BSB01036)
关键词
感染
b型流感嗜血菌
安全性
疫苗
Infection
Haemophilus influenza type B
Safety
Vaccine
