摘要
试验旨在研究玉米赤霉烯酮(ZEA)对肉鸡血清指标、肝脏氧化损伤及毒素残留的影响。将120只1日龄肉鸡随机分成2组,每组设6个重复,每个重复10只。对照组饲喂基础日粮,攻毒组在基础日粮中添加2 mg/kg的ZEA。结果表明,ZEA攻毒使肉鸡血清总蛋白和白蛋白显著降低,天冬氨酸转氨酶、丙氨酸转氨酶、碱性磷酸酶显著上升;ZEA对血清IgA、IgM、IgG及细胞因子IL-2、IL-5、TNF-α水平无显著影响;ZEA使肉鸡肝脏总超氧化物歧化酶和谷胱甘肽过氧化酶活性降低,还原性谷胱甘肽含量下降,丙二醛含量升高;ZEA攻毒组肉鸡肝脏的残留量显著上升。结果提示,ZEA可影响肉鸡血清代谢物水平,造成肝脏氧化损伤,提高肝脏中残留量。
An experiment was conducted to study the effects of zearalenone （ZEA） on serum parameters, hepatic oxidative damage and residue of zearalenone in broilers. A total of 120 chickens were randomly allocated into two groups with six replicates of 10 birds. The dietary treatments were as follows： the control group： the basal diet; the contaminated group： the control diet supplemented with zearalenone （2 mg/ kg）. The results showed that the serum concentrations of total protein and albumin were decreased in the contaminated group; meanwhile, the serum concentrations of aspartate aminotransferase （AST）, alanine aminotransferase （ALT）, and alkaline phosphatase （ALP） were in- creased in the contaminated group. The supplementation of ZEA did not cause significant effects on the levels of IgA, IgG, IgM, IL-2, IL -5 or TNF-α. ZEA increased the levels of malondialdehyde （MDA）, and decreased the concentrations of superoxide dismutase （SOD） and glutathione peroxidase （GSH-Px）. The addition of ZEA increased the residue of ZEA in liver. In conclusion, ZEA could affect serum metabolites, induce hepatic oxidative damage and increase the residue of ZEA in liver.
出处
《畜牧与兽医》
北大核心
2016年第6期10-14,共5页
Animal Husbandry & Veterinary Medicine
基金
淮安市科技成果转化专项资金(HA201511)
关键词
玉米赤霉烯酮
氧化损伤
免疫功能
残留
肉鸡
zearalenone
oxidative stress
immunologic function
residue
broilers
