摘要
目的:探讨盐酸戊乙奎醚注射液治疗有机磷农药中毒的疗效及护理措施。方法:选取汉川市人民医院2013年8月—2014年8月收治的100例重症有机磷农药中毒患者,按随机数字表法分为2组各50例。对照组患者给予阿托品治疗,观察组患者给予盐酸戊乙奎醚注射液治疗。比较2组患者症状消失时间、胆碱酯酶活性恢复时间、住院时间、不良反应发生率,治愈率、病死率的差异,并对护理措施进行总结。结果:观察组患者症状消失时间为(2.34±1.43)h,对照组为(4.01±2.10)h,2组的差异有统计学意义(P<0.05);观察组患者胆碱酯酶活性恢复时间为(18.23±10.01)h,对照组为(34.21±15.34)h,2组的差异有统计学意义(P<0.05);观察组患者住院时间为(5.34±1.3)d,对照组为(13.21±3.14)d,2组的差异有统计学意义(P<0.05);观察组患者不良反应发生率、病死率分别为4%(2/50)、6%(3/50),均明显低于对照组的50%(25/50)、18%(9/50),差异有统计学意义(P<0.05);观察组患者治愈率为94%(47/50),明显高于对照组的82%(41/50),差异有统计学意义(P<0.05)。结论:盐酸戊乙奎醚注射液可有效改善重症有机磷农药中毒患者的症状,提高抢救成功率,不良反应少,是治疗有机磷农药中毒较为理想的抗胆碱药。同时,给予针对性的护理,可提高临床治疗效果,降低病死率。
OBJECTIVE： To probe into the efficacy of penehyclidine hydrochloride injection in treatment of severe organophosphorus pesticide poisoning and nursing measures. METHODS： 100 cases of severe organophosphorus pesticide poisoning admitted into Hanchuan Municipal People＇s Hospital from Aug. 2013 to Aug. 2014 were selected to be divided into two groups via the random number table,with 50 cases in each. The control group were treated with atropine,while the observation group received penehyclidine hydrochloride injection. After treatment,the differences of symptom disappearance time,Ch E recovery time,length of stay,incidence of adverse drug reactions,cure rate andmortality were compared between two group of patients; and the nursing measures were summarized. RESULTS： The symptom disappearance time of observation group was（ 2. 34 ± 1. 43） h,and control group was（ 4. 01 ± 2. 10） h,with statistical significance（P〈0. 05）. The Ch E recovery time of observation group was（ 18. 23 ± 10. 01） h,and control group was（ 34. 21 ± 15. 34） h,with statistical significance（P〈0. 05）. Meanwhile,the length of stay of observation group was（ 5. 34 ± 1. 3） d,and control group was（ 13. 21 ± 3. 14） d,with statistical significance（P〈0. 05）. In observation group,the incidence of adverse drug reactions and mortality were respectively 4%（ 2 /50） and6%（ 3 /50）,lower than that of control group[ 50%（ 25 /50） and 18%（ 9 /50） ],with statistically significant difference（P〈0. 05）. The cure rate of observation group was 94%（ 47 /50）,higher than that of control group 82%（ 41 /50）,with statistically significant difference（P〈0. 05）. CONCLUSIONS： During the treatment of severe organophosphorus pesticide poisoning,penehyclidine hydrochloride injection can effectively improve the symptoms of poisoning and improve the success rate of rescue with few adverse drug reactions,and also can be regarded as an ideal drug for treatment of organophosphorus pesticide poisoning. Me
出处
《中国医院用药评价与分析》
2016年第5期612-614,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
有机磷农药中毒
盐酸戊乙奎醚注射液
阿托品
临床疗效
护理措施
Severe organophosphorus pesticide poisoning
Penehyclidine hydrochloride injection
Atropine
Clinical efficacy
Nursing measures
