摘要
目的:基于中医传承辅助平台(V2.5)软件,分析张佩青教授治疗膜性肾病的用药经验。方法:收集张佩青教授门诊治疗膜性肾病的医案,录入"中医传承辅助平台(V2.5)"软件,采用该软件集成的规则分析、改进的互信息法、复杂系统熵聚类、无监督的熵层次聚类等数据挖掘方法,结合专家本人校审,共同分析药物使用频次、对药配伍、组方特点等。结果:对筛选出的110个处方进行分析,处方中共出现中药93味,确定各种药物的使用频次,药物之间的关联规则,演化得到核心组合16个、新处方8个,张佩青教授确认药物组合及新处方为其治疗膜性肾病的核心用药。结论:张佩青教授治疗膜性肾病特点突出,用药准确细致,中医传承辅助平台(V2.5)软件分析结果与专家临床辨证论治心得基本吻合,该软件可用于名老中医临床经验分析与总结。
Objective： To analyze Professor ZHANG Pei-qing＇s medical experience for membranous nephropathy based on Traditional Chinese Medicine Inheritance Support System（ V2. 5）. Method： ZHANG Peiqing＇s prescriptions for membranous nephropathy patients were collected and logged into the Traditional Chinese Medicine Inheritance Support System（ V2. 5）. Prescription frequency of drugs,combination of paired herbs and prescription characters were defined by using the software＇s integrated regularity analysis, improved mutual information,complex system entropy cluster,unsupervised hierarchical clustering and other data-mining methods and through Professor ZHANG Pei-qing＇s personal proofreading. Result： The 110 prescriptions were screened out and analyzed,involving 93 herbs. After determining the frequency of each herb and the association rules between all herbs,we got 16 core combinations and 8 new prescriptions,and these were confirmed as the core herbs for treating membranous nephropathy by Professor ZHANG Pei-qing. Conclusion： Professor ZHANG Pei-qing＇s prescriptions show outstanding characteristics in treating membranous nephropathy,with a high accuracy. The analytical results obtained by the Traditional Chinese Medicine Inheritance Support System were basically consistent with the professor＇s experience, indicating that the system can be used to analyze and summarize clinical experiences of famous veteran doctors of traditional Chinese medicine.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2016年第12期205-208,共4页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
张佩青
膜性肾病
用药经验
中医传承辅助平台(V2.5)软件
ZHANG Pei-qing
membranous nephropathy
herbal administration experience
Traditional Chinese Medicine Inheritance Support System（V2
5）
