摘要
目的 探讨单纯放疗、同步放化疗治疗宫颈癌患者的疗效及不良反应.方法 研究对象为2010年5月-2012年5月在内蒙古医科大学附属医院接受治疗的127例宫颈癌患者.根据治疗方案分为两组：单纯放疗组65例,同步化放疗组62例.观察两组患者的疗效、不良反应和生存情况.结果 全组患者均顺利完成治疗,中位随访时间为42个月.单纯放疗组完全缓解率为80.00％（52/65）,同步化放疗组完全缓解率为82.26％（51/62）,差异无统计学意义（x2=1.22,P=0.352）.单纯放疗组和同步放化疗组患者的1年总生存率分别为95.38％、95.16％,差异无统计学意义（x2=0.32,P=0.533）;3年总生存率分别为81.54％、90.32％,5年总生存率分别为72.31％、83.87％,差异均具有统计学意义（x2 =5.09,P =0.015;x2=3.87,P=0.039）.46例年龄≥60岁的患者单纯放疗组和同步放化疗组1年总生存率分别为94.62％、93.91％,3年总生存率分别为85.02％、87.25％,5年总生存率分别为70.06％、73.58％,差异均无统计学意义（x2=0.06,P=0.753;x2=1.16,P=0.279;x2=0.48,P=0.511）.单纯放疗组和同步放化疗组不良反应主要以1—2级为主,其中白细胞减少（56.10％∶72.20％）、血小板减少（58.82％∶76.80％）、恶心呕吐（34.04％∶56.90％）发生率的差异均有统计学意义（x2=11.23,P=0.003;x2=11.82,P=0.002;x2=12.77,P=0.000）.结论 同步放化疗治疗宫颈癌的疗效优于单纯放疗,可以提高3年和5年总生存率,但同时也应注意到同步放化疗可能引起的不良反应增加,对于年龄≥60岁的宫颈癌患者同步放化疗并未取得更大的生存获益.
Objective To investigate the curative effects and adverse reactions of pure radiotherapy and concurrent chemotherapy and radiotherapy for patients with cervical cancer.Methods One hundred and twenty-seven patients with cervical cancer who accepted treatment in the Affliated Hospital of Inner Mongolia Medical Unive.rsity from May 2010 to May 2012 were collected.All patients were divided into two groups：pure radiotherapy group （n =65） and concurrent chemotherapy and radiotherapy group （n =62）.The curative effects,adverse reactions and survival of two groups were observed.Results All patients were completed treatment.The median follow-up time was 42 months.The rate of complete response in the pure radiotherapy group was 80.0% （52/65）,and the rate in the concurrent chemotherapy and radiotherapy group was 82.26% （51/62）,with no significant difference （x2 =1.22,P =0.352）.The 1-year overall survival rates in the pure radiotherapy group and the concurrent chemotherapy and radiotherapy group were 95.38% and 95.16% respectively,with no significant difference （x2 =0.32,P =0.533）,but the 3-year overall survival rates were 81.54% and 90.32% respectively,the 5-year overall survival rates were 72.31% and 83.87% respectively,with significant differences （x2 =5.09,P =0.015;x2=3.87,P =0.039）.However,for the patients who were ≥ 60 years,the 1-year overall survival rates in the two groups were 94.62% and 93.91% respectively,the 3-year overall survival rates were 85.02% and 87.25% respectively,the 5-year overall survival rates were 70.06% and 73.58% respectively,with no significant differences （x2 =0.06,P =0.753;x2 =1.16,P =0.279;x2 =0.48,P =0.511）.The adverse reactions were mainly in grades 1-2.There were significant differences in the rates of leucopenia （56.10% vs.72.20%）,thrombocytopenia （58.82% vs.76.80%）,nausea and vomiting （34.04% vs.56.90%） among the two treatment groups （x2 =11.23,P =0.003;x2 =11.82,P=0.002;x2 =12.77,P =0.000）.Conclusion The curative effect of concurrent ch
出处
《国际肿瘤学杂志》
CAS
2016年第6期428-432,共5页
Journal of International Oncology
基金
内蒙古自治区科技计划(20130403) Science and Technology Project of Inner Mongolia of China
关键词
宫颈肿瘤
放射疗法
同步放化疗
Uterine cervical neoplasms
Radiotherapy
Concurrent chemoradiotherapy
