摘要
目的:探讨针灸联合中药对腰椎间盘突出症患者血清细胞因子、丙二醛(malonaldehyd,MDA)、超氧化物岐化酶(Superoxide dismutase,SOD)及血浆血栓素β2水平的影响。方法:112例腰椎间盘突出症患者按照随机分组法分为对照组56例与观察组56例。对照组采用常规西药治疗,观察组采用针灸联合中药治疗。两组均以10 d为1个疗程,连续观察2个疗程。比较两组血清细胞因子、MDA、SOD、血浆血栓素β2水平、VAS评分、疗效及不良反应。结果:两组血清C-反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)白介素-6(Interleukin-6,IL-6)治疗后水平下降(P<0.05);观察组血清CRP、TNF-α、IL-6治疗后水平低于对照组(P<0.05);两组血清MDA治疗后水平下降(P<0.05),而SOD治疗后水平增加(P<0.05);观察组血清MDA治疗后低于对照组(P<0.05),而SOD治疗后水平高于对照组(P<0.05);两组血浆血栓素β2治疗后水平下降(P<0.05);观察组血浆血栓素β2治疗后水平低于对照组(P<0.05);两组VAS治疗后评分降低(P<0.05);观察组VAS治疗后评分低于对照组(P<0.05);观察组总有效率(89.29%)高于对照组(71.43%)(P<0.05);且未出现严重药物相关不良反应。结论:针灸联合中药对腰椎间盘突出症患者作用主要为降低血清细胞因子、MDA、血浆血栓素β2以及提高SOD水平,且治疗疗效显著。
Objective： To explore the acupuncture and moxibustion combined with traditional Chinese medicine on serum cytokines,malondialdehyde（ MDA）,superoxide,（ SOD） and plasma thromboxane β2 of lumbar disc herniation patients. Methods： A total of 112 cases of lumbar disc herniation were randomly divided into control group 56 cases and observation group 56 cases. The control group was treated with routine western medicine and the observation group treated with acupuncture combined with Chinese herbal medicine. The two groups were treated with 10 d for 1 course and 2 courses were observed continuously. Compare two groups＇ serum cytokines,MDA,SOD,thromboxane β2,VAS score,curative effect and adverse reaction. Results： The two groups＇ serum C-reactive protein（ C reactive protein,CRP）,tumor necrosis factor-α（ tumor necrosis factor-α,TNF-α） and interleukin 6（ IL-6） after treatment were decreased（ P〈0. 05）. The levels of serum CRP,TNF-α and IL-6 in the observation group were lower than those in the control group（ P〈0. 05）. The levels of serum MDA after treatment in the two groups were decreased（ P〈0. 05） and the level of SOD after treatment was increased（ P〈0. 05）. The serum MDA in the observation group was lower than that in the control group（ P〈0. 05） and the level of SOD after treatment was higher than that of the control group（ P〈0. 05）. The two groups＇ plasma thromboxane β2 after treatment were decreased（ P〈0. 05）. The observation group＇s plasma thromboxane β2 levels after treatment was lower than the control group＇s（ P〈0. 05）. The score of VAS in the two groups was decreased（ P〈0. 05）. The score of VAS in the observation group was lower than that in the control group（ P〈0. 05）.The total effective rate in the observation group（ 89. 29%） was higher than that in the control group（ 71. 43%）（ P〈0. 05）. And no serious adverse drug reactions occurred. Conclusion： Acupuncture combined with traditional Chinese medi
出处
《中华中医药学刊》
CAS
北大核心
2016年第6期1523-1526,共4页
Chinese Archives of Traditional Chinese Medicine
关键词
针灸
中药
腰椎间盘突出症
细胞因子
丙二醛
超氧化物岐化酶
血栓素β2
acupuncture
traditional Chinese medicine
lumbar disc herniation
cytokine
malondialdehyde
superoxide dismutase
thromboxane β2
