摘要
目的探讨老年患者血脂水平与合并外周动脉粥样硬化(AS)的相关性。方法选择2011年1月~2013年12月西南医院老年病科住院治疗的老年患者593例,根据血管超声结果,将患者分为非AS组164例和AS组429例。采集AS相关危险因素,并统计患者使用药物的情况。结果与非AS组比较,AS组体质量指数[BMI(23.90±4.01)kg/m2 vs(23.09±3.23)kg/m2]、血胱抑素C[(1.00±0.40)mg/Lvs(0.92±0.36)mg/L]、TG水平[(1.72±1.30)mmol/L vs(1.43±0.88)mmol/L]显著增高(P<0.05),年龄、糖尿病、高血压患病率显著增高(P<0.01),而估计肾小球滤过率(eGFR)水平显著降低[(107.18±44.29)ml/(min·1.73 m^2)vs(111.48±35.37)ml/(min·1.73m^2),P<0.05]。年龄、BMI、血胱抑素C、TG水平以及糖尿病、高血压患病率与AS发病呈正相关,而eGFR与AS发病呈负相关(P<0.05)。血TG为老年合并AS的独立预测因素,当血TG≥1.3mmol/L时,合并AS发病风险显著增高。结论老年患者血TG水平与合并AS呈正相关,而且可作为其独立预测指标。
Objective To study the association of serum blood-lipid level and atherosclerosis（AS）in elderly patients.Methods Five hundred and ninety-three elderly patients admitted to our hospital from January 2011 to December 2013 were divided into AS-free group（n=164）and AS group（n=429）according to their angiography.Risk factors for AS and drugs the patients used were analyzed.Results The age was significantly older,and the BMI,serum TG and CysC levels,incidence of hypertension and DM were significantly higher whereas the eGFR was significantly lower in AS group than in AS-free group[23.90±4.01kg/m^2 vs 23.09±3.23kg/m^2,1.72±1.30mg/L vs 1.43±0.88mg/L,1.00±0.40mmol/L vs 0.92±0.36 mmol/L,107.18±44.29ml/（min·1.73 m2）vs 111.48±35.37 ml/（min·1.73 m^2）,P〈0.05].Spearman correlation analysis showed that age,BMI,serum TG and CysC levels,incidence of hypertension and DM were positively associated with AS whereas eGFR was negatively associated with AS.Serum TG level was an independent predictor of AS in elderly patients.Multivariate logistic regression analysis showed that the risk of AS was higher in elderly patients when their serum TG level was≥1.3mmol/L.Conclusion Serum TG level is positively associated with AS in elderly patients and can thus be used as an independent predictor of AS.
出处
《中华老年心脑血管病杂志》
CAS
2016年第6期604-607,共4页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
国家自然科学基金(81370007)
