摘要
目的研究甲磺酸去铁胺对老年脑出血患者血肿及其周围水肿以及功能预后的影响。方法将19例脑出血患者随机分为去铁胺组12例和对照组7例,分析2组患者的影像学资料及入院第15、30及90天的改良Rankin量表评分（mRS）,将2组资料进行比较。结果与去铁胺组比较,对照组1~8d血肿相对吸收量显著增加,差异有统计学意义（0.15±0.18 vs 0.42±0.23,P=0.013）;对照组8~15d血肿相对吸收量显著增加,差异有统计学意义（0.48±0.22 vs 0.74±0.29,P=0.042）。去铁胺组与对照组患者入院第15、30和90天mRS≥3分比例比较,差异无统计学意义（66.7%vs 42.9%,58.3%vs 28.6%,33.3%vs 28.6%,P〉0.05）。结论甲磺酸去铁胺能够抑制老年脑出血患者血肿的吸收。
Objective To study the effect of deferoxamine mesylate on hematoma,perihematoma edema and functional prognosis in elderly intracerebral hemorrhage（ICH）patients.MethodsNineteen ICH patients were randomly divided into deferoxamine mesylate treatment group（n=12）and control group（n=7）.Their imaging data,modified Rankin Scale（mRS）scores on days15,30 and 90after admission were analyzed and compared.Results The hematoma size was significantly larger in control group than in deferoxamine mesylate treatment group on days 1-8and8-15 after admission（0.42±0.23 vs 0.15±0.18,P=0.013;0.74±0.29 vs 0.48±0.22,P=0.042）.No significant difference was found in mRS score≥3between the two groups on days 15,30 and 90after admission（66.7% vs 42.9%,58.3% vs 28.6%,33.3% vs 28.6%,P〉0.05）.Conclusion Deferoxamine mesylate can reduce the hematoma size in elderly ICH patients.
出处
《中华老年心脑血管病杂志》
CAS
2016年第6期574-576,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
关键词
去铁胺
脑出血
血肿
水肿
预后
deferoxamine
cerebral hemorrhage
hematoma
edema
prognosis
