摘要
目的探讨低年龄Duchenne型肌营养不良（DMD）患儿的心电图、心脏超声异常的特点和临床意义。方法采用统计学方法回顾性分析50例3.0~6.9岁DMD患儿的临床资料和检查结果。结果行心电图检查的DMD患儿中93%存在心电图异常表现,以Ⅲ或Ⅴ6导联Q波、PR间期缩短、Ⅴ1导联S波最为常见;所有患儿心脏超声均未出现心肌病表现,但与同年龄正常儿童相比,存在左室舒张末径升高,左室射血分数和左室缩短分数降低。结论 DMD患儿的心脏损害出现较早,早期开展低年龄DMD患儿常规心脏功能评估,有助于减少心源性猝死,延长患儿生命。
Aim To study the cardiac dysfunction of young Duchenne muscular dystrophy（DMD） patients with electrocardiogram and echocardiography.Methods The clinical data and test results of 50 DMD patients aged 3.0-6.9 years old were analyzed retrospectively.Results 93% of patients with electrocardiogram results showed electrocardiographic abnormality.The most common manifestations were abnormal Q wave in leads Ⅲ or V6,shortening PR interval period and abnormal S wave in lead V1.There was no cardiomyopathy in the 50 DMD patients,however,left ventricular end diastolic diameter（LVEDD） was higher compared with normal children of the same age,and left ventricular ejection fraction（LVEF） and left ventricular fractional shortening（LVFS） were lower.Conclusion DMD patients experience cardiac damages in early age.Cardiac function tests,as baseline assessment,are necessary for DMD patients regardless of age,which can help to reduce the sudden cardiac death and prolong lives of DMD patients.
出处
《中国临床神经科学》
2016年第3期267-272,共6页
Chinese Journal of Clinical Neurosciences
基金
首都临床特色应用研究与成果推广(编号:Z151100004015025)
