摘要
目的分析糖皮质激素在治疗儿童急重症肺炎中的应用及对C-反应蛋白的影响。方法选择2012年6月至2014年7月接受治疗的儿童急重症肺炎患者130例,依据治疗方法不同,随机分为观察组和对照组,每组65例。对照组患者给予单独阿奇霉素治疗,观察组患者给予糖皮质激素联合阿奇霉素进行治疗。记录2组患者治疗后肺部啰音时间、咳嗽时间、肺部阴影时间、住院时间等一般情况;比较2组患者治疗前后体内C-反应蛋白(CRP)水平及T淋巴细胞亚群的状态。比较2组治疗方案再感染率及临床疗效。结果 2组患者治疗前体内CRP、CD+3、CD+4、CD+8含量基本相同(P>0.05),治疗后,观察组患者体内CRP、CD+3、CD+4、CD+3水平均显著优于对照组,差异有统计学意义(P<0.05);观察组患者治疗后肺部啰音时间、咳嗽时间、肺部阴影时间、发热时间、住院时间等较对照组明显缩短,差异均有统计学意义(P<0.05);观察组治疗后再感染率显著低于对照组,研究组患者临床总有效率显著高于对照组,差异有统计学意义(P<0.05)。结论糖皮质激素联合阿奇霉素可以有效缩短治疗时间,提高治疗效果,减少术后并发症,安全可靠,适合临床推广应用。
Objective To investigate the application of glucocorticoids in treatment of acute severe pneumonia in children and its effects on C-reactive protein（ CRP）. Methods One hundred and thirty children patients with acute severe pneumonia who were treated in our hospital from June 2012 to July 2014 were enrolled in the study,who were randomly divided into observation group（ n = 65） and control group（ n = 65） according to different therapeutic methods. The patients in control group were given azithromycin only,however,the patients in observation group were treated with glucocorticoid combined with azithromycin. The pulmonary rale time,cough time,pulmonary shadow time,hospital stay after treatment were observed and compared between two groups,moreover,the levels of CRP and T lymphocyte subsets were detected before and after treatment,moreover,the clinical therapeutic effects and reinfection rates were observed and compared between two groups. Results Before treatment,the levels of CRP,CD＋3,CD＋4,CD＋8were basically similar in the two groups（ P〈0. 05）.After treatment,the levels of CRP,CD＋3,CD＋4,CD＋8in observation group were superior to those in control group（ P〈0. 05）. After treatment,the pulmonary rale time,cough time,pulmonary shadow time,hospital stay in observation group were significantly shorter than those in control group（ P〈0. 05）. After treatment the infection rate in observation group was significantly lower than that in control group,however,the total effective rate in observation was significantly higher than that in control group（ P〈0. 05）. Conclusion Glucocorticoid combined with azithromycin can effectively shorten treatment time,improve therapeutic effects,decrease postoperative complications,which is safe and reliable,suitable for clinical application.
出处
《河北医药》
CAS
2016年第11期1608-1610,共3页
Hebei Medical Journal
基金
湖北省自然科学基金资助项目(编号:2014FFB04510)
关键词
糖皮质激素
阿奇霉素
儿童急重症肺炎
C-反应蛋白
glucocorticoids
azithromycin
acute severe pneumonia in children
C-reactive protein
