摘要
目的拟阐明NADPH氧化酶Nox4与非诺贝特抗高血压心肌肥大效应的关系。方法构建腹主动脉缩窄(abdominal aorta coarctation,AAC)诱导的高血压大鼠模型,观察非诺贝特对高血压大鼠左心室肥大的影响。结果非诺贝特可显著抑制AAC高血压大鼠左心室肥大。与假手术组比较,AAC组左心室中NADPH氧化酶Nox4蛋白和mRNA水平均显著增加;与AAC组比较,非诺贝特剂量依赖性降低AAC高血压大鼠左心室中NADPH氧化酶Nox4蛋白和mRNA水平。结论降低NADPH氧化酶Nox4表达可能是非诺贝特发挥抗高血压心肌肥大效应的重要机制。
Aim To elucidate the relation between NADPH oxidase Nox4 and the protective effect of fenofribate against cardiac hypertrophy. Methods Abdominal aorta coarctation（AAC）-induced hypertensive rats were constructed to observe the effect of fenofribate on left ventricular hypertrophy. Results Fenofribate could inhibit left ventricular hypertrophy in AAC-induced hypertensive rats. Compared with sham group,the mRNA and protein levels of NADPH oxidase Nox4 were significantly elevated in left ventricular tissue of AAC group;compared with AAC group,fenofribate reduced the mRNA and protein levels of NADPH oxidase Nox4 in left ventricular tissue in a dose-dependent manner.Conclusion Reducing NADPH oxidase Nox4 expression could be a crucial mechanism of fenofribate against hypertensioninduced cardiac hypertrophy. It will provide further theoretical and experimental support for fenofribate curing hypertension- induced myocardial hypertrophy.
出处
《中国动脉硬化杂志》
CAS
北大核心
2016年第6期557-560,共4页
Chinese Journal of Arteriosclerosis
基金
广东省自然科学基金(2015A030310076)
