摘要
目的 探讨慢性乙型肝炎患者临床转归及其影响因素,为乙型肝炎患者的预后判断提供参考.方法 选取2009年1月至2014年6月间收治的慢性乙型肝炎患者102例作为研究对象,将其中发生肝硬化或肝癌的32例患者设为病例组,未发生肝硬化或肝癌的70例患者设为对照组,对比两组患者的一般资料及乙型肝炎病毒（HBV） DNA、血清丙氨酸氨基转移酶（ALT）等指标.结果 乙型肝炎病毒表面抗原（HBsAg）转阴者累计5例,慢性乙型肝炎65例,肝硬化、肝癌32例.经单因素Logistic回归分析,病例组与对照组患者年龄、性别、饮酒史、HBV DNA水平及血清ALT水平之间的差异均有统计学意义（均P＜ 0.05）.以是否发生肝硬化、肝癌为因变量,以各种单因素为自变量,对两组间具有统计学意义的单因素进行多因素Logistic回归分析,结果显示年龄较大、男性、有饮酒史、HBV DNA水平较高及血清ALT水平较高是导致慢性乙型肝炎患者发生肝硬化、肝癌的危险因素（OR值分别为9.94、14.36、8.25、13.01、120.32）.结论 年龄较大、男性、有饮酒史、HBV DNA水平较高及血清ALT水平较高的慢性乙型肝炎患者发生肝硬化、肝癌的概率较高.对具有高危因素的患者应进行系统性干预,以减少进展为肝硬化、肝癌,提高患者生命质量.
Objective To investigate the clinical outcomes of patients with chronic hepatitis B and its influencing factors,and provide reference for the prognosis of patients with hepatitis B.Methods 102 patients with chronic hepatitis B from January 2009 to June 2014 were selected and divided into the case group of 32 patients and the control group of 70 patients according to whether to occur with cirrhosis or liver cancer.The two groups of patients were analyzed and compared for general information,HBV DNA,serum ALT and other indicators.Results The cumulative cases of negative HBsAg,chronical hepatitis B,liver cirrhosis and liver cancer were 5,65 and 32,respectively.Univariate Logistic regression analysis showed that the differences between the two groups in age,sex,drinking history,HBV DNA levels and serum ALT levels were statistically significant （all P 〈 0.05）.Whether to cirrhosis or liver cancer was the dependent variable,the statistically significant single factors between the two groups were the independent variable,multivariate Logistic regression analysis showed that older age,male sex,alcohol abuse,high level of HBV DNA and high level of serum ALT were the risk factors of leading to cirrhosis,liver cancer for the patients with chronic hepatitis B （OR values were 9.94,14.36,8.25,13.01,120.32,respectively）.Conclusions The older age,male,alcohol history,high level of HBV DNA and high level of serum ALT are higher risk factors for patients with chronic hepatitis B to development of cirrhosis and liver cancer.Patients with risk factors should be gave systematic interventions to reduce progression to cirrhosis,liver cancer and improve the quality of life.
出处
《肿瘤研究与临床》
CAS
2016年第5期334-337,共4页
Cancer Research and Clinic
关键词
肝炎
乙型
慢性
肝硬化
原发性肝癌
临床转归
Hepatitis B,chronic
Cirrhosis
Primary hepatocarcinoma
Clinical outcomes
