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含维生素C肠外营养液的稳定性考察 被引量:10

Investigation on Stability of TPN Solution Containing Vitamin C
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摘要 目的:考察我院临床常见肠外营养液配伍稳定性。方法:配伍液在4种不同条件下放置8 h,观察其外观、p H变化,测定维生素C含量。结果:在含有复合氨基酸的溶液中维生素C的含量随着时间推移不断下降,4 h后溶液由无色变为黄色,维生素C含量降低10%,但p H无明显变化;维生素C在不含复合氨基酸的溶液在6 h内性质稳定。结论:维生素C注射液不建议加入含有复方氨基酸的肠外营养液中使用,宜单独使用。 Objective: To study the stability of total parenteral nutrition (TPN) solution used in our hospital. Methods: The ap- pearance and pH of the compatibility solution were observed and the content of vitamin C was determined in 8 h after the compatibility. Results: The content of vitamin C in compound amino acid solution was decreased with the time, and the solution turned yellow in 4 h and the content of vitamin C was decreased by 10%, while no notable change in pH value was shown. The solution without compound amino acid was stable in 6 h. Conclusion: Vitamin C injection mixed with TNP solution containing compound amino acid is not recom- mended, and vitamin C should be used alone.
出处 《中国药师》 CAS 2016年第6期1203-1206,共4页 China Pharmacist
关键词 肠外营养液 稳定性 维生素C 高效液相色谱 Total parenteral nutrition Stability Vitamin C HPLC
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