摘要
目的 研究不同潮气量通气对肺炎并发呼吸衰竭患儿呼吸力学参数的影响。方法 将2012年1月至2014年1月攀枝花市第三人民医院收治的120例肺炎并发呼吸衰竭患儿按随机数字表法分为常规潮气量组(8~12 m L/kg)和小潮气量组(6~7 m L/kg),各60例,对患儿进行肺动态顺应性、气道阻力、气道闭合压等呼吸力学参数和肺氧合功能及并发症发生情况进行检测,评估不同潮气量通气对患儿呼吸力学参数及治疗效果的影响。结果 小潮气量组和常规潮气量组上机治疗后的第1、3、5、7日肺动态顺应性呈上升趋势[小潮气量组:(3.86±0.31)m L/cm H2O、(4.65±0.89)m L/cm H2O、(5.14±1.22)m L/cm H2O、(6.15±1.64)m L/cm H2O比(2.65±0.22)m L/cm H2O;常规潮气量组:(3.05±0.14)m L/cm H2O,(3.15±1.10)m L/cm H2O,(4.05±0.85)m L/cm H2O,(4.33±0.64)m L/cm H2O比(2.60±0.23)m L/cm H2O],气道阻力呈下降趋势[小潮气量组:(75.52±4.51)cm H2O/(L·s),(67.53±3.31)cm H2O/(L·s),(43.68±5.69)cm H2O/(L·s),(31.51±6.29)cm H2O/(L·s)比(97.72±5.76)cm H2O/(L·s);常规潮气量组:(80.23±1.64)cm H2O/(L·s),(72.35±4.24)cm H2O/(L·s),(50.69±1.72)cm H2O/(L·s),(34.45±2.81)cm H2O/(L·s)比(94.81±7.67)cm H2O/(L·s)](P〈0.05);小潮气量组患儿总并发症发生率显著低于常规潮气量组[10.0%(6/60)比26.7%(16/60),P〈0.05];机械通气治疗24 h后,小潮气量组和常规潮气量组患儿Pa O2均高于治疗前[(9.89±0.39)k Pa、(6.18±1.04)k Pa,(8.23±0.47)k Pa、(6.22±1.28)k Pa],小潮气量组高于常规潮气量组(P〈0.05);小潮气量组和常规潮气量组患儿动脉血二氧化碳分压、肺泡气-动脉血氧分压差、氧合指数均低于治疗前,且小潮气量组低于常规潮气量组[(5.42±0.21)k Pa比(6.57±0.90)k Pa;(1.39±0.53)k Pa比(1.96±0.93)k Pa;4.2±2.3比6.1±2.4,P
Objective To explore the effect of different tidal volumes of ventilation on respriatory mechanical parameters of pneumonia children with respiratory failure. Methods Total of 120 children of pneumonia with respiratory failure in Panzhihua City Third People' s Hospital from Jan. 2012 to Jan. 2014 were included and assigned into conventional numerical tidal volume group( 8-12 m L / kg) and low tidal volume group( 6-8 m L / kg) according to the random number table method,60 cases in each group. The dynamic lung compliance,airway resistance,airway occlusion pressure and other respiratory mechanical and oxygenation parameters and complication incidence were monitored to evaluate the effect of different tidal volumes of ventilation on respiratory mechanics parameters in the children. Results The 1,3,5,7 day dynamic lung compliance of the low tidal volume group and conventional tidal volume group were in upward trend[low tidal volume group:( 3. 86 ± 0. 31) m L / cm H2 O,( 4. 65 ± 0. 89) m L / cm H2 O,( 5. 14 ± 1. 22) m L / cm H2 O,( 6. 15 ± 1. 64) m L/cm H2 O vs( 2. 65 ± 0. 22) m L / cm H2O; conventional tidal volume group:( 3. 05 ±0. 14) m L / cm H2 O,( 3. 15 ± 1. 10) m L / cm H2 O,( 4. 05 ± 0. 85) m L / cm H2 O,( 4. 33 ± 0. 64) m L / cm H2 O vs( 2. 60 ± 0. 23) m L / cm H2 O ],airway resistance decreased [low tidal volume group:( 75. 52 ±4. 51) cm H2 O /( L·s),( 67. 53 ± 3. 31) cm H2 O /( L·s),( 43. 68 ± 5. 69) cm H2 O /( L·s),( 31. 51 ±6. 29) cm H2 O /( L·s) vs( 97. 72 ± 5. 76) cm H2 O /( L·s); conventional tidal volume group:( 80. 23 ±1. 64) cm H2 O /( L·s),( 72. 35 ± 4. 24) cm H2 O /( L·s),( 50. 69 ± 1. 72) cm H2 O /( L·s),( 34. 45 ±2. 81) cm H2 O /( L·s) vs( 94. 81 ± 7. 67) cm H2 O /( L·s) ]( P〈0. 05); overall complication rate of the low tidal volume group was significantly lower than the conventional tidal volume group[10. 0%( 6 /60) vs2
出处
《医学综述》
2016年第11期2256-2259,共4页
Medical Recapitulate
关键词
肺炎
呼吸衰竭
机械通气
呼吸力学
Pneumonia
Respiratory failure
Mechanical ventilation
Respiratory mechanics