摘要
目的探讨质子泵抑制剂(PPI)以奥美拉唑为主的三联疗法治疗小儿消化性溃疡的临床疗效。方法将2013年10月至2014年10月海南省万宁市人民医院收治的90例消化性溃疡患儿采用随机数字表法分为观察组和对照组,各45例。观察组患儿行以奥美拉唑为主的三联疗法治疗,对照组患儿行以雷尼替丁H2受体拮抗剂为主的三联疗法治疗。评价两组患儿的临床治疗效果,检测幽门螺杆菌(Hp)根除率,并观察患儿不良反应的发生情况。结果观察组总有效率为95.6%(43/45),高于对照组的80.0%(36/45),差异有统计学意义(P<0.05)。观察组Hp根除率高于对照组[93.3%(42/45)比73.3%(33/45)],差异有统计学意义(P<0.05)。观察组不良反应的总发生率为13.3%(6/45),对照组为15.6%(7/45),比较差异无统计学意义(P>0.05)。结论以奥美拉唑为主的三联疗法治疗小儿消化性溃疡的临床疗效显著,Hp根除率高,且安全性好,值得临床推广应用。
Objective To analyze the clinical effect of proton pump inhibitor omeprazole-based triple therapy in children with peptic ulcer. Methods Total of 90 peptic ulcer patients in People＇ s Hospital of Wanning City in Hainan from Oct. 2013 to Oct. 2014 were divided into the observation group（ 45 cases） and the control group（ 45 cases） according to the random number table method. The observation group was treated by triple therapy with omeprazole as main drug,and the control group was treated by tripe therapy with ranitidine H2 receptor antagonist as main drug. The clinical treatment effect were assessed,Hp eradicate rate was detected,and the occurrence of adverse reactions of the two groups was observed. Results Total effective rate of observation group was higher than the control group[95. 6%（ 43 /45） vs 80. 0%（ 36 /45） ],the difference was statistically significant（ P〈0. 05）. Hp eradication rate of the observation group was higher than the control group[93. 3%（ 42 /45） vs 73. 3%（ 33 /45） ],the difference was statistically significant（ P〈0. 05）. The overall incidence of adverse reactions of the observation group was 13. 3%（ 6 /45）,of the control group was 15. 6 %（ 7 /45）,the difference was not statistically significant（ P〉0. 05）. Conclusion The triple therapy with omeprazole as the main drug in the treatment of pediatric peptic ulcer has significant clinical effect,high Hp eradication rate,and good safety,thus is worthy of clinical popularization and application.
出处
《医学综述》
2016年第11期2253-2255,共3页
Medical Recapitulate
