摘要
目的 :观察急性白血病 (AL)患者化疗前后血小板平均体积 (MPV)的变化及其在造血恢复中的意义。方法 :使用全自动血细胞分析仪及相应试剂对两组化疗前后疗效不同的AL患者 ,采集静脉血测定MPV ,用于比较AL第一疗程化疗后完全缓解 (CR)和部分缓解 (PR)组 ,未缓解 (NR)组 ,两组化疗前后MPV的变化及其恢复时间。结果 :CR +PR组 ,化疗前MPV与正常成人相比差异不大 (P >0 0 5 ) ,NR组则有明显的差异 (t=3 36 0 ,P <0 0 0 1)。化疗前后比较显示 :CR +PR组MPV平均下降 2 6fl(P<0 0 0 1) ,而NR组轻微上升 0 7fl(P >0 0 5 )。CR +PR组MPV平均恢复时间为 (14± 2 )d ,任何一系血细胞达到正常水平时间为(2 1± 2 )d(t=3 990 ,P <0 0 0 1)。另外在油镜下发现两组之间存在有明显的形态与体积的变化。结论 :化疗前后对急性白血病患者MPV变化的观察 ,可能有利于指导化疗方案的选择 。
Objective:To investigate the changes of MPV in patients with acute leukemia before and after chemotherapy and its significance in predicating hematopoietic recovery.Methods:MPV was measured by using BECKMAN CLULTER HMX Autohemocytometer and changes in MPV compared in two groups(CR+PR group and NR group) before and after chemotherapy, respectively. In addition, mean time for MPV to recover to normal was evaluated in CR+PR group.Results:No statistically significant difference in MPV was found between CR+PR group before chemotherapy and normal controls ( P >0 05), while a significant difference was observed between NR group and normal controls (t=3 360, P <0 001). MPV decreased by an average of 2 6fl in CR+PR group compared with that before chemotherapy ( P <0 001) and slightly increased by 0 7 fl in NR group ( P >0 005). In CR+PR group, the mean time for MPV to recover to normal was 14±2 days and that for any lineage of hemopoiesis to reconstitute was 21±2 days ( t =3 990, P <0 001).Morphologic observations confirmed the above findings.Conclusion:Observations before and after chemotherapy is helpful in the choice of chemotherapeutic protocols and increment in MPV might be used as a predicative parameter for early bone marrow hemapoietic recovery.
出处
《临床肿瘤学杂志》
CAS
2002年第4期256-257,共2页
Chinese Clinical Oncology
