摘要
耐辐射奇球菌是迄今为止发现的最具辐射抗性的生物之一。其体内的Ppr I蛋白在整个DNA辐射损伤修复过程中起着必不可少的作用,ppr I作为一个细胞全局性的开关基因,协调控制DNA损伤响应与修复过程中众多细胞通路的基因表达。本文探讨了Ppr I在耐辐射奇球菌抗辐射和抗氧化中的生物学功能、相关结构功能以及对其他原核及真核生物抗逆性的影响,并展望了其潜在的生物学新功能与意义,旨在为进一步研究耐辐射奇球菌的辐射抗性机制提供理论依据。
Deinococcus radiodurans is one of the most radio-resistant organisms discovered so far. PprI, a protein which was found in Deinococcus radiodurans plays an indispensable role in the processes of DNA damage repair, it also acts as a general switch to orchestrate the expression of a number of DNA damage response （DDR） proteins which involved in numerous cellular pathways. To provide theoretical basis for further study on the mechanism of Deinococcus radiodurans＇ radiation resistance. The biological functions of PprI in radio-resistance and anti-oxidation, its structure function and effects on stress resistance in other prokaryotic and eukaryotic organisms were discussed, the prospect of its novel potential function and significance.
出处
《核农学报》
CAS
CSCD
北大核心
2016年第6期1106-1110,共5页
Journal of Nuclear Agricultural Sciences
基金
国家自然科学基金(31210103904
31370102
31570058)
国家重点基础研究发展计划(2015CB910600)
