摘要
目的：比较膝骨关节炎患者关节镜清理前后关节液中IL－Iβ、NO含量的变化，探讨可否将此作为评价膝关节镜干预效果的指标，并进一步探讨关节镜技术的临床应用价值。方法：选取2013年10月～2014年2月潍坊医学院附属医院关节外科收治的膝骨关节炎患者100例纳入研究对象，所有患者均行关节镜清理术，比较手术前和手术后3、6、12个月时膝骨关节炎WOMAC评分及关节液中IL－Iβ、NO含量。结果：手术后3、6、12个月患者膝骨关节炎严重指数评分均低于术前（P＜0．05），关节液中IL－Iβ、NO含量也均低于术前（P＜0．05），关节液中IL－Iβ、NO含量与膝骨关节炎WOAMC评分呈正相关。结论：关节镜下膝关节腔清理术能够减少关节液中IL－Iβ、NO含量，同时改善膝关节功能，是治疗早中期KOA的理想方法。
Objective：To compare the changes of IL-1β、NO content in synovial fluid of knee osteoarthritis patients before and after arthroscopic debridement,and investigate whether it could be used as an index for evaluating the interventional effect of knee arthroscopy, and to futher disscuss the clinical application value of knee osteoarthritis.Methods：A totlal of 100 cases of knee osteoarthritis admitted from 2013 October to 2014 February were enrolled and treated with arthroscopic debridement.Before surgery and 3,6,12 months after sur-gery ,knee joint function and IL-1β、NO content in synovial fluid were compared.Results：3,6,12months after surgery, the WOMAC scores were lower than those before surgery （P〈0.05）,IL-1β、NO content in synovial fluid were lower than those before surgery （P〈0. 05）;the levels of IL-1β、NO in synovial fluid with knee OA were positively correlated with WOMAC socores （P〈0.05）.Conclusion：Ar-throscopic debridement surgery could reduce IL -1β、NO content and improve knee function, and it might be an ideal way for early knee OA.
出处
《中国伤残医学》
2016年第10期7-9,共3页
Chinese Journal of Trauma and Disability Medicine
关键词
膝骨关节炎
白细胞介素-1β
NO
关节镜清理术
Knee osteoarthritis
Interleukin - 1β （ IL - 1β ）
NO
Arthroscopic debridement surgery
