摘要
目的分析慢性鼻窦炎筛窦黏膜细菌学分布及药物敏感性,为临床治疗慢性鼻窦炎提供科学依据。方法从2014-01—2014-12间选取54例慢性鼻窦炎患者,功能性鼻内镜术中取筛窦黏膜进行细菌培养并测试常用抗菌药物对病菌的敏感性,15例单纯鼻中隔偏曲或鼻窦囊肿术者作为健康对照组。结果 54例慢性鼻窦炎患者中,41份样本培养出细菌,占总例数的75.9%。而对照组仅有5份样本培养出细菌,两组比较差异有统计学意义(P<0.05)。对革兰氏阴性菌敏感的有亚胺培南、头孢噻肟、头孢吡肟等。对革兰氏阳性菌敏感的有庆大霉素、万古霉素、诺氟沙星等,而其他抗菌药物的敏感度较低。实验组行β-内酰胺酶菌株鉴定,45株病菌中,17株具有耐药性,检出率为37.8%。结论细菌感染在慢性鼻窦炎的发病中起重要作用,且耐药现象严重,临床合理应用抗生素或根据药敏选择抗生素可以提高患者的预后。
Objective To analyze the distribution of chronic sinusitis sinus mucosa bacteriology and drug sensitivity,provide a scientific basis for the clinical treatment of chronic sinusitis. Methods Selected 54 cases of patients with chronic sinusitis in January 2014- December 2014,functional endoscopic sinus surgery mucosal taken for bacterial culture and sensitivity test commonly used antibiotics for bacteria,and 15 cases of simple cysts deviated septum or sinus surgeon was selected as control group. Results In the 54 cases of chronic sinusitis patients,41 samples was cultured bacteria,which was 75. 9% of the total number. While the control group only 5 samples cultured bacteria,the difference was statistically significant（ P 0. 05）. The gram- negative bacteria was sensitive to imipenem,cefotaxime,cefepime. Against gram- positive bacteria sensitive was gentamicin,vancomycin,norfloxacin,and less sensitive to other antimicrobial drugs. Experimental group β- lactamases was identified the bacteria in 45,17 having a resistance,the detection rate was 37. 78%. Conclusion Bacterial infection plays an important role in the pathogenesis of chronic sinusitis,and drug resistance is serious,rational use of antibiotics or choice of antibiotics based on susceptibility can improve the prognosis of patients.
出处
《黑龙江医学》
2016年第5期428-430,共3页
Heilongjiang Medical Journal
基金
东莞市科技局项目(201510515000325)
