摘要
目的探讨妊娠期糖尿病孕妇连续动态血糖监测效果及对孕产妇和围产儿结局的影响。方法本研究选取136例于2012年1月至2014年5月在我院行产前检查并确诊为妊娠期糖尿病的孕妇,平均年龄为31.5±10.5岁。根据产妇情况分为两组,对照组孕妇仅接受常规的孕期保健,实验组孕妇在常规孕期保健计划基础上,采取连续血糖监测,进行了有效的药物和饮食干预控制血糖。最终选得实验组和对照组各68例。比较两组患者一般资料、孕产妇和围产儿结局情况。结果两组产妇之间年龄、身高、体重、体重指数、病程、孕龄、经产妇、糖化血红蛋白、胰岛素剂量、糖尿病性视网膜病变数、尿白蛋白排泄率、吸烟者和孕前严重低血糖情况比较均无显著差异（P〉0.05）。实验组与对照组8周时糖化血红蛋白差异均无统计学意义（P〉0.05）;而33周和36周时实验组糖化血红蛋白均明显减低,差异均具有统计学意义（P〈0.05）。实验组与对照组8周和33周时每日自我监测血糖值差异均无统计学意义（P〉0.05）;而36周时实验组每日自我监测血糖值明显减低,差异均具有统计学意义（P〈0.05）。按3.6~7.5 mmol/L标准,实验组与对照组每日自我监测血糖所占百分比差异均具有统计学意义（P〈0.05）。两组孕妇的羊水过多、早产、胎盘早剥和新生儿低血糖的比较,差异具有统计学意义（均P〈0.05）;其他指标如活产婴儿、流产、孕期体重增加、先兆子痫、剖腹产、出生时的胎龄、出生体重、先天畸形、大胎龄儿、2小时血浆葡萄糖量和严重的新生儿低血糖两组比较,差异均无统计学意义（P〉0.05）。结论连续动态血糖监测可以监测妊娠糖尿病孕妇的血糖波动情况,可以使血糖控制更加及时有效,对妊娠结局的部分指标具有一定的指示作用,尤其是对羊水过多、早产、胎盘早剥和新生儿低血糖的影响�
Objective To investigate the effect of continuous ambulatory blood glucose monitoring on maternal and perinatal outcomes in pregnant women with gestational diabetes mellitus.Methods 136 pregnant women with gestational diabetes at average age of 31.5 ＋ 10.5 were involved in this study,and divided into two groups（68 patients in each group） according to the maternal situation.The control group received regular prenatal care in the hospital,and the experimental group received continuous ambulatory blood glucose monitoring besides regular prenatal care.The general information,maternal and perinatal outcome of the two groups were recorded and compared.Results The maternal age,height,weight,body mass index,course of disease,gestational age,maternal,glycosylated hemoglobin,insulin,diabetes retina lesion and urinary albumin excretion rate,and pre pregnancy severe hypoglycemia cases between two groups had no significant difference（P〉0.05）.There was no significant difference on glycosylated hemoglobin levels between two groups at 8weeks（P〉0.05）.The glycosylated hemoglobin levels in experimental group at 33 and 36 weeks were significantly lower than that of control group（P〈0.05）.There was no significant difference on daily self monitoring blood glucose between two groups at 8 and 33 weeks（P〉0.05）,while it was significantly lower at 36 weeks in experimental group than that of control group（P〈0.05）.The amniotic fluid,premature birth,placenta and neonatal hypoglycemia between two groups had significantly difference（P〈0.05）.The other indicators of live births,abortion,pregnancy weight gain,pre eclampsia,caesarean birth,birth weight,2 hours blood glucose and severe neonatal hypoglycemia between two groups had no statistically difference（P〉0.05）.Conclusion Continuous dynamic blood glucose monitoring can monitor the fluctuation of blood glucose in pregnant women with gestational diabetes,which can make the blood glucose control more timely and effective,and it has a certain effect on
出处
《标记免疫分析与临床》
CAS
2016年第5期557-561,共5页
Labeled Immunoassays and Clinical Medicine
关键词
连续动态血糖监测
孕妇
影响
Continuous dynamic glucose monitoring
Pregnant women
Influence
