摘要
目的:探讨舍曲林联合认知训练治疗儿童青少年抑郁症的临床疗效。方法:收集儿童青少年抑郁症患者70例,随机分为观察组和对照组各35例,2组均给予盐酸舍曲林片治疗,观察组还给予认知训练治疗,观察汉密尔顿抑郁量表(HAMD)和副反应量表(TESS)评分。结果:治疗8周后,对照组和观察组的有效率分别为80.0%、94.3%,差异有统计学意义(P<0.05)。治疗1、2、4、8周后,2组HAMD评分低于治疗前(P<0.05),且观察组的HAMD评分低于对照组(P<0.05)。治疗4、8周后,观察组的TESS评分低于对照组(P<0.05)。结论:舍曲林联合认知训练治疗儿童青少年抑郁症效果优于单纯舍曲林治疗,副反应轻。
Objective：To evaluate the clinical efficacy of sertraline combined with cognitive training on treatment of children and adolescents with depression. Methods： Total 70 children or adolescent with depression were enrolled, and were divided into groups of observation and control, with 35 cases in each group. Both the groups were treated with sertraline, and the observation group was given cognitive training. Scores of Hamilton depression scale（HAMD） and treatment emergent symptom scale（TESS） were measured. Results： After 8 weeks of treatment, the efficiency of the control group and the observation group were 80.0% and 94.3% respectively（P〈0.05）. After 1, 2, 4, 8 weeks of the treatment, the HAMD scores of the 2 groups were lower than those before the treatment（P〈0.05）, and the HAMD score of the observation group was lower than that of the control group（P〈0.05）. After 4 and 8 weeks of the treatment, the TESS scores of the observation group were lower than those of the control group（P〈0.05）. Conclusion： Sertraline combined with cognitive training in children and adolescents with depression was better than sertraline therapy alone, with slight side reactions.
出处
《神经损伤与功能重建》
2016年第3期233-235,共3页
Neural Injury and Functional Reconstruction
关键词
儿童抑郁症
舍曲林
认知训练
childhood depression
sertraline
cognitive training
