摘要
目的探讨地佐辛联合丙泊酚静脉麻醉下行阴道超声引导下取卵术对体外受精妊娠结局的影响。方法常规体外受精(in vitro fertilization,IVF)或卵胞浆内单精子显微注射术(intracytoplasmic sperm injection,ICSI)不孕女性765例,依据麻醉方式分为观察组234例和对照组531例,观察组于地佐辛联合丙泊酚静脉麻醉下行阴道超声引导下取卵术,对照组肌内注射盐酸哌替啶50mg 10min后行阴道超声引导下取卵术,比较2组获卵数、获卵率、IVF受精率、ICSI受精率、2原核(pronucleus,PN)受精率、2PN卵裂率、优质胚胎率、移植胚胎数、生化妊娠率、临床妊娠率、胚胎着床率、流产率、出生率,记录2组术后疼痛、恶心、呕吐等不良反应发生率。结果观察组优质胚胎率(51.21%)明显高于对照组(46.21%)(P<0.05);观察组获卵数[(14.70±6.96)枚]、获卵率[(67.69±18.60)%]、IVF受精率(81.68%)、ICSI受精率(83.07%)、2PN受精率(65.20%)、2PN卵裂率(98.45%)、移植胚胎数[(2.06±0.32)枚]、生化妊娠率(63.20%)、临床妊娠率(54.40%)、胚胎着床率(34.78%)、流产率(8.82%)、出生率(47.20%)与对照组[(13.63±7.05)枚、(67.84±17.60)%、80.17%、82.88%、65.91%、98.65%、(2.02±0.31)枚、64.62%、58.77%、37.79%、8.95%、52.63%]比较差异均无统计学意义(P>0.05);观察组术后轻微疼痛(2.14%)、明显疼痛(0.85%)及恶心(4.27%)发生率低于对照组(19.77%、3.77%、25.42%)(P<0.05),呕吐发生率(1.28%)与对照组(0.94%)比较差异无统计学意义(P>0.05)。结论地佐辛联合丙泊酚静脉麻醉下行阴道超声引导下取卵术对体外受精不孕患者妊娠结局无明显影响,且不良反应轻。
Objective To investigate the influence of dezocine combined with propofol on the outcome of in vitro fertilization（IVF）in transvaginal ultrasound-guided oocyte retrival.Methods A total of 765 infertile female patients undergoing IVF or intracytoplasmic sperm injection（ICSI）were divided into observation group（n=234）and control group（n=531）according to different anesthesia methods.Observation group received transvaginal oocyte retrival under anesthesia with dezocine combined with propofol,and control group received transvaginal oocyte retrival 10 min after intramuscular injection of 50 mg pethidine hydrochloride.The average oocytes retrieved,oocytes retrieved rate,IVF fertilization rate,ICSI fertilization rate,2 pronucleus fertilization rate,2 pronucleus cleavage rate,good quality embyo rate,number of embryos transferred,biochemical pregnancy rate,clinical pregnancy rate,embryo implantation rate,abortion rate and birth rate were compared between two groups,and the incidences of mild pain,nausea,emesis and other adverse reactions were recorded after operation.Results The good quality embyo rate was significantly higher in observation group（51.52%）than that in control group（46.21%）（P〈0.05）.There were no significant differences in the number of average oocytes retrieved（14.70±6.96,13.63±7.05）,oocytes retrieved rates（（67.69±18.60）%,（67.84±17.60）%）,IVF fertilization rates（81.68%,80.17%）,ICSI fertilization rates（83.07%,82.88%）,2pronucleus fertilization rates（65.20%,65.91%）,2pronucleus cleavage rates（98.45%,98.65%）,number of embryos transferred（2.06±0.32,2.02±0.31）,biochemical pregnancy rates（63.20%,64.62%）,clinical pregnancy rates（54.40%,58.77%）,embryo implantation rates（34.78%,37.79%）,abortion rates（8.82%,8.95%）or birth rates（47.20%,52.63%）between observation group and control group（P〈0.05）.The incidences of mild pain,obvious pain and nausea after operation were significantly lower in observation group（2.14%,0.85%,4.27%�
出处
《中华实用诊断与治疗杂志》
2016年第6期611-613,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
洛阳市科技计划发展项目(1101050A)
关键词
体外受精
阴道超声引导下取卵术
地佐辛
丙泊酚
盐酸哌替啶
In vitro fertilization
transvaginal ultrasound-guided oocyte retrival
dezocine
propofol
pethidine hydrochloride
