摘要
主观性认知功能减退可能是轻度认知功能障碍的临床前阶段。帕金森病随病程进展可出现认知功能损害。伴有主观性认知功能减退的帕金森病患者多表现为认知量表整体评分正常,但某些分项领域异常,且可能同时合并局部脑皮层密度、厚度改变及多巴胺能水平改变。正确认识主观性认知功能减退在帕金森病认知损害发展中的作用,对早期干预和避免认知功能损害发展至不可逆阶段有重要意义。本文就帕金森病患者主观性认知功能减退的临床特点及研究进展作一综述。
Subjective cognitive decline（SCD）is possible the preclinical stage of mild cognitive impairment which may occur along with the development of Parkinson＇s disease（PD）.The overall cognitive scale score is commonly normal,but some items of the scale are abnormal in PD patients complicated with SCD,and the patients are usually complicated with regional cerebral cortex density and thickness changing,as well as dopamine level changing.Full recognition of the influence of SCD on PD is very important for the early intervention and prevention of cognitive impairment from being irreversible.This paper reviews the clinical features and research progress of SCD in PD patients.
出处
《中华实用诊断与治疗杂志》
2016年第6期528-530,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
2012年度国家临床重点专科建设项目(2012)
关键词
帕金森病
主观性认知功能减退
认知功能损害
Parkinson＇s disease
subjective cognitive decline
cognitive impairment
