摘要
目前已经报道约18种肾上腺髓质肿瘤相关基因突变,基于基因突变类型的靶向治疗前景广阔。肾上腺皮质腺瘤中,原发性醛固酮腺瘤的体细胞突变携带率约40%,但真正的致病基因还需进一步的研究。基因芯片、蛋白组学帮助快速发现更多致病候选基因。米托坦为目前唯一有效的治疗肾上腺皮质癌的药物,国际临床随机双盲实验已证实米托坦联合依托泊苷、阿霉素和顺铂可延长疾病无进展生存时间。
Adrenal medulla tumors have been reported to be associated with 18 kinds of somatic and germline genes mutation. With the development of genomics and proteomics,recent findings reveal the pathogenesis of adrenocortical tumor and new marks for the adrenocortical carcinoma prognosis. Mitotane as the essential drug to the adrenocortical carcinoma combine with etoposide,doxorubicin and cisplatin will improve progression-free survival.
出处
《基础医学与临床》
CSCD
2016年第6期856-859,共4页
Basic and Clinical Medicine
关键词
肾上腺肿瘤
嗜铬细胞瘤
醛固酮腺瘤
皮质醇腺瘤
皮质癌
adrenal tumor
pheochromocytoma
aldosterone-producing adenoma
cortical-producing adenoma
adrenocortical carcinoma
