摘要
目的观察儿童变应性鼻炎患者标准化变应原皮下特异性免疫治疗（subcutaneous specific immunotherapy,SCIT）的长期疗效。方法将2007年1月~2009年8月收集的2 36例儿童变应性鼻炎患者分为2组,其中120例接受了标准化尘螨变应原SCIT,另外116例接受了鼻喷激素、口服抗组胺等药物保守治疗（对照组）。应用视觉模拟量表（visual analogue scale,VAS）评分和鼻结膜炎相关生活质量问卷（rhinoconjunctivitis quality of life questionnaire,RQLO）对患者的疗效进行评估。结果变应性鼻炎患儿经历3年的SCIT疗程后,在继续随访3个月、1年、3年和5年的症状VAS平均积分分别为2.3±0.7、2.4±0.6、1.6±0.4、1.9±0.5,显著低于治疗前的积分（P〈0.001）,而RQLQ积分分别为7.7±1.6、7.4±1.1、4.3±0.7、4.1±0.9,也显著低于治疗前的积分（P〈0.001）,在随访的各时间点的VAS和RQLO积分均显著低于对照组（P〈0.001）。比较单一尘螨阳性与含尘螨在内的多变应原阳性的儿童变应性鼻炎患儿经过SCIT疗程后,各随访时间点的VAS及RQLO积允发现积分没有显著差异（P〉0.05）。所有治疗均没有发生严重不良事件。结论标准化变应原SCIT治疗对尘螨阳性的儿童变应性鼻炎患者具有长期疗效,且安全性好。含尘螨的多变应原阳性患儿能获得同样的疗效。
OBJECTIVE To observe the long-term therapeutic efficacy of standardized specific subcutaneous immunotherapy on persistent allergic rhinitis in children.METHODS From Jan.2007 to Aug.2009,236 children with persistent allergic rhinitis were divided into two groups,which 120 cases underwent standardized house dust mite allergen subcutaneous specific immunotherapy（SCIT）,another 116 cases accepted a serious of steroids nasal spray and oral antihistamine（control group）.The efficacy of the patients was evaluated by using the visual analog scale（VAS） and Rhino conjunctivitis quality of life questionnaire（RQLQ）.RESULTS After patients underwent 3-years SCIT,the VAS score was 2.3 ±0.7,2.4±0.6,1.6±0.4,1.9±0.5,and the RQLQ score was 7.7±1.6,7.4 ±1.1,4.3 ±0.7,4.1 ±0.9,respectively,at the follow-up period of 3 month,1year,3 years and 5 years,and both scores were significantly lower than the score of pre-treatment（P〈0.001）.Compared the single dust mite allergen positive patients with multiple allergens positive patients,both VAS and RQLQ scores were not significantly changed at each follow-up period after SCIT（P〈0.05）.No serious adverse events occurred in all treatments.CONCLUSION The standardized specific immunotherapy has the long-term efficacy for dust mite positive children with persistent allergic rhinitis.It demonstrated a similar effect in both single dust mite positive patients and multiple allergens positive patients.
出处
《中国耳鼻咽喉头颈外科》
CSCD
2016年第5期283-286,共4页
Chinese Archives of Otolaryngology-Head and Neck Surgery
基金
湖南省225人才工程项目基金资助(湘卫201313)
湖南省科技计划项目(S2013F1023)联合资助
关键词
儿童
鼻炎
变应性
常年性
鼻炎
变应性
季节性
治疗结果
Child
Rhinitis
Allergic
Perennial
Rhinitis
Allergic
Seasonal
Treatment Outcome
