摘要
他汀类药物除了具有调脂作用外,还具有抑制炎症反应、改善内皮细胞功能、保护肠道黏膜屏障等作用,因此可以用于缓解急性胰腺炎的临床症状、缩短疗程、改善预后,在治疗中发挥积极作用。随着他汀类药物的广泛应用,其相关的不良反应也逐渐被认识,其中包括急性胰腺炎。世界卫生组织数据库中列出了多种可导致急性胰腺炎的他汀类药物,但相关机制目前尚不明确。鉴于以上可能相互矛盾的诸多研究结论,对他汀类药物引起急性胰腺炎的现状、机制以及在治疗中的作用进行了综述,认为进一步的双盲试验对于探究他汀类药物与急性胰腺炎的相关性是必要的。
Besides regulating lipid,statins can inhibit inflammatory response,improve the function of endothelial cells,and protect intestinal mucosal barrier. Therefore,it can be used to relieve the clinical symptoms of acute pancreatitis,shorten the course of treatment,and improve the prognosis,and can play an important role in treatment. With the wide application of statins,their adverse effects are gradually being recognized,including acute pancreatitis. The World Health Organization database lists a variety of statins that can cause acute pancreatitis,but related mechanisms remain unknown. In view of the contradictory results mentioned above,this article reviews the current status,mechanisms of action,and roles of statins in acute pancreatitis and points out that further double- blind trials are needed to investigate the association between statins and acute pancreatitis.
出处
《临床肝胆病杂志》
CAS
2016年第5期964-967,共4页
Journal of Clinical Hepatology
