摘要
目的 探讨肌动蛋白凝胶蛋白（Transgelin）在胃癌组织及癌旁组织中的表达差异及其临床意义.方法 应用免疫组织化学方法测定癌组织及癌旁组织中Transgelin的表达,分析其与临床病理特征的关系.结果 Transgelin在胃腺癌中高表达率为55.56％ （70/126）,高于癌旁组织的44.44％ （56/126）,差异有统计学意义（Z=-7.264,P＜0.01）.胃腺癌组织中Transgelin的高表达与患者的年龄、性别、TNM分期、远处转移、分化类型、浸润深度及组织类型无明显相关（P＞0.05）,但与患者的的淋巴结转移、肿瘤大小和5年生存期明显相关（P＜0.05）.结论 Transgelin的高表达与胃癌的发生发展相关.
Objective To investigate the expression level and the clinical significance of Transgelin on gastric adenocarcinomas tissues and paired non-neoplastic tissues.Methods The express of Transgelin was detected by using immunohistochemistry,and the relationship Transgelin level with clinicopathogical factors was explored.Results The positive expression of Transgelin was in cancer tissues was 55.56% （70/126）,higher than 44.44% （56/126）,compared to the levels in non-neoplastic tissues P 〈 0.05 （the Wilcoxon test）.Up-expression of Transgelin was not correlated with patients＆#39; age,nor with sex,TNM stage,distant metastasis,differentiation grade,the depth of invasion and tissue type,but related with lymphnode metastasis （P 〈 0.05）,tumor size （P 〈 0.05） and 5-years survival of patients （P 〈 0.01）.Conclusion Transgelin may play important roles in the development and progression of gastric carcinoma.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2016年第5期1339-1341,共3页
Chinese Journal of Experimental Surgery
