摘要
目的研究加速康复外科(ERAS)在肝癌肝切除术中的临床应用效果及价值。方法回顾性研究哈尔滨医科大学附属第一医院普外科2013年6月-2015年6月肝癌行肝切除术患者172例,其中ERAS组92例,对照组80例,比较分析两组患者术后肝功能指标(ALT、AST、TBIL)、营养免疫指标(ALB、PA、淋巴细胞计数)、术后并发症、术后康复及卫生经济学等相关指标。结果肝功能指标:ERAS组患者术后1、7天ALT、AST及TBIL水平分别为(216.3±141.7)U/L、(70.1±29.4)U/L;(184.0±155.8)U/L、(39.1±17.5)U/L;(22.4±8.7)μmol/L、(20.0±7.5)μmol/L,对照组分别为(304.5±226.2)U/L、(83.9±48.5)U/L;(294.1±273.0)15/L、(49.2±33.8)U/L;(26.9±15.6)μmol/L、(24.6±10.8)μmol/L,两组比较差异有统计学意义(F=9.33,9.84,9.26,P〈0.05)。营养免疫指标:ERAS组患者术后第7天ALB、PA水平分别为(35.3±4.4)g/L、(136.3±34.1)mg/L,对照组为(33.6±4.2)g/L、(108.0±32.5)mg/L,两组比较差异有统计学意义(F=4.97,4.54,P〈0.05);ERAS组患者术后1、7天淋巴细胞计数为(0.9±0.3)×10^9/L、(1.5±0.5)×10^9/L,对照组为(0.7±0.3)×10^9/L、(1.3±0.5)×10^9/L,两组比较差异有统计学意义(F=7.37,P〈0.05)。手术并发症:ERAS组患者术后出血0例,胆漏2例,肝功能障碍2例,感染3例;对照组术后出血3例,胆漏1例,肝功能障碍2例,感染3例,两组比较差异均无统计学意义(P〉0.05);腹水ERAS组11例,对照组23例,差异有统计学意义(x^2=7.609,P〈0.05)。术后康复及卫生经济学指标:ERAS组离床活动时间、排气时间、术后住院时间及住院总费用分别为(1.7±0.5)d、(2.3±0.6)d、(9.8±2.3)d、(4.6±0
Objective To investigate the effects and value of enhance recovery after surgery (ERAS) applica- tion in patients with hepatoceilular carcinoma underwent liver resection. Methods One hundred and seventy-two patients with hepatocellular carcinoma underwent liver resection in the first affiliated hospital of Harbin medical uni- versity from June 2013 to June 2015, ERAS group (92 cases) and control group (80 cases) were retrospectively studied. Laboratory indicators ( ALT, AST, TBIL, ALB, PA, lymphocyte count), postoperative complications, postoperative hospitalization days and total hospitalization expenses were compared between two groups. Results For postoperative liver functional indicators (ALT, AST, TBIL) , ERAS group Day 1 and Day 7 were respectively (216.3 ±141.7) U/Land (70.1 ±29.4) U/L, (184.0±155.8) U/L and (39.1±17.5) U/L, (22.4± 8.7 ) μmol/L and (20.0± 7.5 ) μmol/L, control group were respectively (304.5 ± 226.2) U/L and (83.9 ±48.5 10.8 0.05 U/L, (294. 1 ±273. 0) U/L and (49.2 ±33. 8) U/L, (26.9 ± 15. 6) μmol/L and (24. 6 ± μmol/L, the difference between two groups was statistically significant ( F = 9. 33, 9. 84, 9. 26, P 〈 For postoperative nutritional indicators ( ALB, PA ) , ERAS group Day 7 were respectively ( 35.3 ± 4.4) g/Land (136. 3 ±34. 1) mg/L, control group were respectively (33. 6 ±4. 2) g/L and (108.0 ± 32.5) mg/L, the difference was statistically significant ( F = 4. 97, 4.54, P 〈 0.05 ). For postoperative immune indicators (lymphocyte count), ERAS group Day 1 and Day 7 were respectively (0.9 ±0.3) × 10^9/L and (1.5 ± 0.5 ) × 10^9/L, control group were respectively (0.7 ± 0.3) × 10^9/L and ( 1.3 ± 0.5) × 10^9/L, the difference was statistically significant ( F = 7.37, P 〈 0.05 ). For postoperative complications ( hemorrhage, bile fistula, hepatic dysfunction, infection) were no statistically significant differences (P 〉 0.05 ), how
出处
《国际外科学杂志》
2016年第4期249-254,共6页
International Journal of Surgery
基金
黑龙江省青年科学基金(QC2010124)
黑龙江省教育厅科学技术研究(12541290)
关键词
肝切除术
肝肿瘤
加速康复外科
Hepatectomy
Liver neoplasms
Enhance recovery after surgery