摘要
1概述内质网（endoplasmic reticulum,ER）蛋白质折叠在生理上是至关重要的,它的破坏导致内质网应激（endoplasmic reticulum stress,ERS）触发动脉粥样硬化（atherosclerosis,AS）发生发展。未折叠蛋白反应（unfolded protein response,UPR）是目前研究最为透彻的ERS信号通路,
The unfolded protein response is the most thorough study of signaling pathways among endoplasmic reticulum stress at present. Numerous studies have shown that the unfolded protein response mediates vascular cell death and plaque instability,which are closely related to clinical progression of atherosclerosis. Inositol-requiring enzyme 1（ IRE1） is an evolutionarily most-conserved endoplasmic reticulum transmembrane sensor of the unfolded protein response.IRE1 activation may mediate the functional spliced XBP1 production or JNK translational activation,and then activate downstream signaling pathways. IRE1 cascade is involved in the physiological and pathological processes of atherosclerosis.Here we review the effect of IRE1 cascade mediated by endoplasmic reticulum stress on the arterial wall endothelial cells,vascular smooth muscle cells and macrophages structure and function,and summarize the role of IRE1-XBP1 pathway and IRE1-JNK pathway in development of atherosclerosis and vulnerable plaque formation.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2016年第6期1147-1152,共6页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.81403217)
关键词
内质网应激
未折叠蛋白反应
需肌醇酶1
级联反应
动脉粥样硬化
Endoplasmic reticulum stress
Unfolded protein response
Inositol-requiring enzyme 1
Cascade
Atherosclerosis
