摘要
目的:观察益气活血清热化湿方对Hp(+)的消化性溃疡Hp根除率、溃疡愈合情况的影响;探讨Hp在根除过程中可能出现的球形变异。方法:采用随机数字表法将80例Hp阳性的消化性溃疡患者分成对照组及治疗组,每组40例。两组均给予西药标准三联疗法,疗程2周,在此基础上对照组给予奥美拉唑镁肠溶片20 mg,1次/d,服用4周。治疗组联合中药益气活血清热化湿方治疗,2次/d,总疗程均为6周。总疗程结束后2周行14C呼气试验(urea breathe test,UBT);复查胃镜观察并记录溃疡的愈合情况,统计治疗后内镜下溃疡愈合的有效率;胃体、胃窦各取1块组织行快速尿素酶试验(rapid urease test,RUT);取胃窦组织行免疫组化法(gastric mucosa immunohistochemistry test,GMIT)检测Hp。记录并评估上述3种不同检测方法的检测结果,确定最终的根除率。结果:治疗组内镜疗效总有效率为97.5%(39/40),明显优于对照组87.5%(35/40)(P<0.05)。治疗组Hp根除率77.5%(31/40),亦明显高于对照组55%(22/40)(P<0.05)。治疗后三种检测方法得出的Hp阳性总个数分别为UBT(12个)、RUT(8个)、GMIT(24个),呼气试验、快速尿素酶试验Hp阳性检出率均低于免疫组化法(P<0.05)。免疫组化染色涂片中发现大量球形幽门螺杆菌。结论:益气活血清热化湿方结合标准三联法较单纯标准三联疗法能更为有效地促进溃疡的愈合,提高Hp的根除率。
Objective： To observe the effect of Yiqi Huoxue Qingre Huashi Recipe（ YHQHR,a recipe capable of supplementing qi,activating blood,clearing heat,and dissipating dampness） on ulcer healing and Helicobacter pylori（ Hp） eradication rate in Hp positive patients and explore coccoid Hp occurrence in the eradication. Methods： Totally 80 Hp positive peptic ulcer patients were assigned to the treatment group and the control group by random digit table,40 in each group. All patients received standard triple therapy of western medicine for 2 successive weeks. Those in the control group additionally took omeprazole enteric coated tablet,20 mg each time,once per day for 4 successive weeks. Those in the treatment group additionally took YHQHR,twice per day for 6successive weeks.14 C breathe test（ UBT） was performed at week 3 after ending the whole course of treatment. The ulcer healing was observed by endoscopy and recorded. The effective rate of ulcer healing under endoscope was statistically calculated. Rapid urease test（ RUT） was performed in one small piece of tissues from corpora ventriculi and sinuses ventriculi. Gastric mucosa immunohistochemical test（ GMIT）,another method,was conducted to indicate Hp existence. Results： Obtained from the above three test methods were recorded and assessed to decide the final eradication rate. Results The total curative effect under gastroscopy was 97. 5%（ 39 out of 40 cases） in the treatment group,obviously higher than that in the control group（ 80%,32 out of 40 cases）（ P 0. 05）. The treatment group＇s eradication rate of Hp was 77. 5%（ 31 out of 40 cases）,obviously better than that of the control group 55%（ 22 out of 40 cases）（ P 0. 05）. The total positive Hp numbers after treatment was UBT（ 12）,RUT（ 8）and GMIT（ 24）,respectively. The Hp positive rate detected by BUT and RUT was lower than Hp positive rate detected by GMIT（ P 0. 05）. A large amount of coccoid Hp was observed under immunohistochemical staining pictures. C
出处
《辽宁中医杂志》
CAS
北大核心
2016年第5期978-981,I0003,共5页
Liaoning Journal of Traditional Chinese Medicine
基金
江苏省科委社会发展基金(BS2006506)
关键词
益气活血
清热化湿
幽门螺杆菌
免疫组化
supplementing qi and activating blood
clearing heat and dissipating dampness
Helicobacter pylori
immunohisto-chemical test
