摘要
最新研究表明,肠道菌群与血管内炎症性疾病具有重要关联,肠道菌群通过多种机制促进肥胖及动脉粥样硬化。同时,肠道菌群可通过破损的肠黏膜进入血循环,诱发内毒素血症,引起多种炎症性疾病。针对上述发病机制,近年来多种益生菌在临床与实验研究中均表现出一定效果,如抑制炎症状态、改善肠道症状、恢复菌群稳态等。现对近年肠道菌群与血管内炎症性疾病的相关性研究做一综述。
Recent studies have showed the important link between gut microbiota and vascular inflammation. Gut microbiota promotes the occurrence of obesity and atherosclerosis through several different kinds of mechanisms. Additionally,gut microbiota may enter blood circulation through damaged intestinal mucosa,leading to endotoxemia and many kinds of infectious diseases. Targeting the above pathogenesis,probiotics exhibit unique therapeutic effects,such as inhibiting the inflammatory state,improving bowel symptoms,restoring flora steady and more. By reviewing the latest research studies on this topic,we are able to look into the relationship between gut microbiota and vascular inflammatory diseases.
出处
《心血管病学进展》
CAS
2016年第3期263-267,共5页
Advances in Cardiovascular Diseases
基金
国家自然科学基金项目(81328025)
上海市自然科学基金项目(12ZR1432200)
国家中医临床研究基地业务建设科研专项(JDZX2012114)
关键词
肠道菌群
血管
炎症
Gut microbiota
Vascular
Inflammation
