摘要
目的:探讨云南汉族人群中CD6基因多态性与慢性丙型肝炎病毒(HCV)感染的关系。方法:随机抽取云南地区汉族人群HCV慢性感染患者434例,健康对照人群444例;采用TaqMan探针基因分型方法对2组人群的CD6基因3个SNPs(rs17824933、rs12360861、rs11230563)进行基因分型,构建CD6基因单倍型,评估上述3个SNPs与HCV慢性感染的关系。结果:两组人群CD6基因SNP-rs17824933(C>G)、SNP-rs12360861(G>A)和SNP-rs11230563(C>T)基因型频率和等位基因频率比较,差异无统计学意义(P>0.05);2组人群的SNP-rs17824933(C>G)、SNP-rs12360861(G>A)和SNP-rs11230563(C>T)单倍型频率比较,差异无统计学意义(P>0.05)。结论:此次调查的云南汉族群体的CD6基因SNP-rs17824933(C>G)、SNP-rs12360861(G>A)和SNP-rs11230563(C>T)与HCV慢性感染无关。
Objective： To investigate the association between CD6 gene polymorphism and chronic HCV chronic infection of Han population in Yunnan province. Methods： 434 HCV chronic infectious patients and 444 healthy individuals of Han Chinese population in Yunnan province were recruited for this study. Three single nucleotide polymorphisms （SNPs） of SNP-rs17824933, SNP-rs12360861 and SNP-rs11230563 of CD6 gene were determined by real-time TaqMan polymerase chain reaction and the haplotypes were constructed. Then evaluating the association correlation of these SNPs and haplotypes with HCV chronic infection. Results： The comparison of frequencies of allele and genotype of both groups of SNP-rs17824933 （C 〉 G） , SNP-rs12360861 （G 〉 A） and SNP-rsl1230563 （C 〉 T） showed that differences were not statistically significant （P 〉 0.05 ）. The frequency of haplotypes con- structed by SNP-rs17824933 （C 〉 G）, SNP-rs12360861 （G 〉 A） and SNP-rs11230563 （C 〉 T） showed no significant difference （P 〉 0. 05）. Conclusion： SNP-rs17824933 （C 〉 G）, SNP- rs12360861 （G 〉 A） and SNP-rsl1230563 （C 〉 T） in the CD6 were not associated with HCV chronic infection in the Han population in Yunnan province.
出处
《贵阳医学院学报》
CAS
2016年第5期527-531,共5页
Journal of Guiyang Medical College
基金
国家自然科学基金(81160197)
吴阶平医学基金(320.6750.13395)
