摘要
目的利用3.0T MRI观察正常胎儿标本脊髓颈膨大最大横断面及其相对位置关系随孕周变化的规律。方法随机选取44例16~42孕周胎儿标本,行3D-T2WI和T2WI-SPC序列扫描,对所得图像三维重建,观察及测量以下参数：1颈膨大最大横断面面积：选取C4-T1脊神经区间内各椎体中心及椎间盘中心水平分别测量颈膨大横断面面积,选取最大面积,绘制最大横断面面积随孕周变化的生长曲线;2颈膨大最大横断面与椎体的相对位置关系;3比较性别间差异。结果 1颈膨大最大横断面积随孕周呈线性增加,与孕周的相关方程分别为：最大横断面积（cm2）=0.01×孕周-0.12,R2=0.91,P〈0.05;2颈膨大最大横断面与椎体相对位置关系：16~28孕周胎儿颈膨大最大横断面约位于C5/6椎间盘中心水平,29~42孕周胎儿颈膨大横断面约位于C5~C5/6中心水平,此位置随孕周增加而逐渐轻度上移;3颈膨大最大横断面面积与性别没有明显统计学差异（P〉0.05）。结论高场磁共振可准确反映胎儿颈膨大最大横断面积及相对位置与孕周变化的规律,建立了正常胎儿脊髓颈膨大生长发育的磁共振影像图谱及数据库。
Objective To investigate the normal development of fetal cervical enlargement,its maximum cross-sectional area and its relative position at different gestational ages using postmortem MRI. Methods A total of 44 fetal specimens ranging from 16-42 gestational weeks were enrolled. Three-dimensional（ 3D） T2-weighted（ WI） imaging and Sampling Perfection with Application-optimized Contrast using differenced flip Angle Evolution（ T2W-SPC） of the cervical spine were performed and then images were reconstructed in the coronal,axial,and sagittal planes. The follow-ing lobular parameters were measured： 1 the relationship between maximum cross-sectional area of cervical enlargement and gestational age; 2 the relative position of cervical enlargement at different gestational ages; 3 the significant differences in cervical enlargement maximum cross-sectional section area between sexes. Results 1 There were significant linear relationships between the maximum cross-sectional area and gestational ages（ cervical enlargementmaximum cross-sectional area = 0. 01 × gestational age- 0. 12,R2= 0. 91,P 0. 05）; 2 The maximum section of fetal cervical enlargement was located in the center of C5 /6 at 16-28 gestational weeks and in the center of C5-C5 /6 at 29-42 gestational weeks. The relative position of the maximum cross-sectional area of fetal enlargement gradually increased over gestation; 3 There was no significant difference in cervical enlargement maximum cross-sectional section area between sexes. Conclusion High field MRI clearly shows the maximum cross-sectional area of cervical enlargement and its relative position over gestation. We have established an MRI image map and database of normal fetal cervical enlargement.
出处
《山东大学学报（医学版）》
CAS
北大核心
2016年第5期74-78,共5页
Journal of Shandong University:Health Sciences
基金
国家自然科学基金(31371213)
山东省自然科学基金(ZR2013HM091)
关键词
脊髓颈膨大
胎儿标本
磁共振成像
脊神经
Cervical enlargement
Fetal specimen
Magnetic resonance imaging
Cervical nerve
