摘要
青少年发病的成年型糖尿病2型（MODY2）由葡萄糖激酶（GCK）基因突变所致，以空腹血糖及糖化血红蛋白水平轻度升高并保持稳定状态为主要表现，多不增加糖尿病并发症及相关代谢疾病的发生风险，无需降糖治疗。但对于妊娠期患者，若胎儿未携带突变基因，妊娠相关并发症及巨大儿发生风险增加，故此类患者需积极降糖治疗。
Maturity-onset diabetes of the young （MODY） caused by glucokinase （GCK） gene mu- tation is called MODY2. Previous study has demonstrated that the levels of fasting blood glucose and glycated hemoglobin （HbAlc） in MODY2 increase slightly and keep stable. It will not raise the incidence of compli- cations of diabetes and other related metabolic disease. Accordingly, there is no need to give treatment. But for pregnant women, if the fetus is without GCK gene mutation, the risk of macrosomia and perinatal morbidi- ty will increase. Therefore, it is necessary to lower the level of blood glucose.
出处
《国际内分泌代谢杂志》
2016年第3期180-183,共4页
International Journal of Endocrinology and Metabolism
基金
国家临床重点专科建设项目（2011）
