摘要
高血压病并发左室肥厚(LVH)概率大于50%,LVH是多种心脑血管疾病的独立危险因素。高血压病等心血管疾病不仅是血液动力学的改变,而是伴随着血管重塑、炎症水平上升和自噬异常的病理过程。本课题组认为:'虚、瘀'病机状态下,高血压LVH的发生是心脏受邪气(过高血压、AngⅡ、炎症等)侵袭合心脏正气(心肌细胞自噬)不足,有形实邪产生过多而吞噬清除不足蓄积的结果。以往研究着重强调邪气的祛除,未重视器官本身的作用,该理论的提出对今后高血压LVH的治疗具有一定的指导意义。
The probability of hypertension complicated with left ventricular hypertrophy(LVH)is more than 50%,LVH is an independent risk factor for various cardiovascular and cerebrovascular diseases.Cardiovascular diseases such as hypertension are not only hemodynamic changes,but also pathological processes accompanied by vascular remodeling,rising levels of inflammation and autophagy abnormalities.Our research group believes that under the pathogenesis of‘deficiency and blood stasis’,the occurrence of hypertension LVH is the result of the invasion of pathogenic factors(hypertension,Ang II,inflammation,etc.)on the heart and the insufficiency of healthy qi(autophagy of myocardial cells),the excessive production of visible and solid pathogens and the insufficient accumulation of phagocytosis and clearance.Previous studies have emphasized the removal of pathogenic factors without paying attention to the function of organs themselves.The theory has certain guiding significance for the treatment of hypertension LVH in the future.
作者
曾勇
任卫琼
文爱珍
蔺晓源
刘侃
谭元生
范伏元
ZENG Yong;REN Wei-qiong;WEN Ai-zhen;LIN Xiao-yuan;LIU Kan;TAN Yuan-sheng;FAN Fu-yuan(Hunan University of Chinese Medicine,Changsha410007,China;The First Affiliated Hospital,Hunan University of Chinese Medicine,Changsha410208,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2019年第10期4836-4838,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(No.81473616)
湖南省自然科学基金项目(No.2016JJ6116)~~
关键词
局部正邪理论
自噬
高血压左室肥厚
发生原因
The theory of local vital qi and pathogen
Autophagy
Hypertensive left ventricular hypertrophy
Occurrence reason
