摘要
目的探讨长期强化降糖治疗对2型糖尿病患者生活质量及心血管事件的影响。方法选取延安大学附属医院2009年2月—2010年7月收治的2型糖尿病患者136例,根据随机数字表法分为强化降糖组和标准降糖组,各68例。标准降糖组患者糖化血红蛋白（Hb A1c）控制目标为6.5%-7.5%,强化降糖组Hb A1c控制目标为〈6.5%。比较两组患者干预前（T_0）、干预3年（T_1）、干预5年（T_2）时Hb A1c水平及空腹血糖（FBG）,T_0和T_2时生活质量;患者均随访5年,记录随访期间心血管事件（大血管并发症、微血管并发症、血管事件复合终点）及低血糖发生率。结果 T_0时两组患者Hb A1c水平及FBG比较,差异无统计学意义（P〉0.05）;T_1、T_2时强化降糖组患者Hb A1c水平及FBG低于标准降糖组（P〈0.05）;T_1、T_2时两组患者Hb A1c水平及FBG均低于T_0时（P〈0.05）。T_0时两组患者世界卫生组织生存质量测定简表（WHOQOL-BREF）评分比较,差异无统计学意义（P〉0.05）;T_2时强化降组患者WHOQOL-BREF评分高于标准降糖组（P〈0.05）。两组患者大血管并发症及微血管并发症发生率比较,差异无统计学意义（P〉0.05）;强化降糖组患者血管事件复合终点发生率低于标准降糖组,低血糖发生率高于标准降糖组（P〈0.05）。结论长期强化降糖治疗可提高2型糖尿病患者的生活质量,降低心血管事件发生率,但需要注意预防低血糖的发生。
Objective To investigate the impact of long- term intensive hypoglycemic therapy on quality of life and cardiovascular events of patients with type 2 diabetes mellitus. Methods A total of 136 patients with type 2 diabetes mellitus were selected in the Affiliated Hospital of Yan＇ an University from February 2009 to July 2010,and they were randomly divided into A group and B group according to random number table,each of 68 cases. The control target of Hb A1 cof A group was 6. 5%to 7. 5%,while that of B group was less than 6. 5%. Hb A1 cand FBG before intervention,after 3 years of intervention,after 5years of intervention were compared between the two groups; quality of life was evaluated before intervention,after 5 years of intervention, respectively; incidence of cardiovascular events（ including macrovascular complications, microvascular complications and composite endpoints of cardiovascular events） and hypoglycemia were recorded during the 5- year follow up.Results No statistically significant differences of Hb A1 cor FBG was found between the two groups before intervention（ P〈0. 05）,while Hb A1 cand FBG of B group were statistically significantly lower than those of A group after 3 years of intervention,after 5 years of intervention（ P〈0. 05）; after 3 years of intervention,after 5 years of intervention,Hb A1 cand FBG of the two groups were statistically significantly lower than those before intervention（ P〈0. 05）. No statistically significant differences of WHOQOL-BREF score was found between the two groups before intervention（ P〈0. 05）,while WHOQOL-BREF score of B group was statistically significantly higher than that of A group after 5 years of intervention（ P〈0. 05）. No statistically significant differences of incidence of macrovascular complications or microvascular complications was found between the two groups（ P〈0. 05）; incidence of composite endpoints of cardiovascular events of B group was statistically significantly lower than that of A group,while incidence
出处
《实用心脑肺血管病杂志》
2016年第4期31-34,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
糖尿病
2型
强化降糖治疗
生活质量
心血管事件
Diabetes mellitus
type 2
Intensive hypoglycemic therapy
Quality of life
Cardiovascular events
