摘要
人类白细胞抗原-G（Human Leukocyte Antigen G,HLA-G）属于非经典的HLA-Ⅰ类分子,最早发现表达在母胎界面的绒毛外滋养层细胞.相对于经典的HLA-Ⅰ类分子,HLA-G具有独特的启动子区域、基因多态性有限、严格的组织分布及递呈抗原种类不多等特点[1].近年来,免疫耐受分子HLA-G与病毒感染的关系得到了广泛的研究,其基因多态性与病毒易感性相关,病毒感染可诱导HLA-G表达或刺激可溶性HLA-G、IL-10以及干扰素分泌等;形成多种免疫调控机制诱导病毒逃逸机体的免疫监视及防御功能.本文就HLA-G在病毒感染中的研究进展作一综述.
Human leukocyte antigen-G （HLA-G） is a non-classical HLA class I molecule, characterized by low DNA polymorphism and by its limited tissue distribution under normal physiological conditions. Recently, HLA-G polymorphisms have now been reported to be involved in viral infectious diseases; and the interference of viral proteins with HLA-G intracellular trafficking or IL-10, interferon secretion have been described to modulate HLA-G expression during infections. In this review, we summarize the features of HLA-G expression by type of infections detailing the state of knowledge for each pathogenie agent.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
2016年第2期244-248,共5页
Chinese Journal of Experimental and Clinical Virology
基金
国家自然科学基金（31370920）
浙江省医药卫生科技计划项目（2015KYB438）
