摘要
目的 探讨慢性乙型肝炎患者HBV-DNA定量水平分布情况及其与家族史及其他相关临床指标、血清标志物的关系.方法 收集901例乙型肝炎患者年龄、性别、病程、家族史、诊断等资料,同时检测HBV-DNA定量、HBV-M定量、肝功能各项指标,并对其进行有序Logistic回归分析.结果 单因素分析显示：在乙型肝炎患者中年龄、病程、诊断及丙氨酸氨基转移酶（ALT）、总胆红素（TBiL）、球蛋白（GLB）、HBsAg、HBeAb、HBeAg水平与HBV-DNA定量密切相关（P=0.000-0.041）;多因素有序Logistic回归分析显示：HBeAg、TBiL、家族史与HBV-DNA定量密切相关（P分别为0.000、0.000、0.008）.结论 了解与HBV-DNA定量相关的临床指标对于了解乙型肝炎的感染状态、抗病毒疗效评价及预后判断具有重要的应用价值.
Objective To investigate the distribution of HBV-DNA level in patients with chronic hepatitis B and its relationship with the family history and other related clinical indexes and serum markers. Method The age,sex,med-ical history,family history,diagnosis and other data of 901 patients with hepatitis B were collected,and the quantita-tive and liver function indexes of HBV-DNA and HBV-M were also detected. Application of ordinal logistic regres-sion analysis data. Result Univariate analysis showed that age, medical history, diagnosis and the levels of TBiL, ALT,GLB,HBsAg,HBeAb,HBeAg were closely correlated with HBV-DNA levels in patients with hepatitis B（ P=0. 000-0. 041）; Multivariate ordinal logistic regression analysis showed that HBeAg,TBiL levels and family history were closely correlated with HBV-DNA respectively（P=0. 000,P=0. 000,P=0. 008）. Conclusion Understanding the quantitative clinical parameters of HBV-DNA has important application value in understanding the status of hep-atitis B infection,antiviral efficacy evaluation and prognosis.
出处
《中国临床医生杂志》
2016年第5期29-32,共4页
Chinese Journal For Clinicians
基金
国家"十二五"科技重大专项(2012ZX10005-004)
