摘要
目的：探讨长脉宽1064 nm Nd：YAG激光治疗趾甲真菌病的疗效及安全性。方法对确诊的104例（461个趾甲）趾甲真菌病患者，根据年龄段分为Ⅰ组（≥60岁）和Ⅱ组（〈60岁），按照SCIO评分及病甲位置的差异分为不同亚组；所有患者病甲均使用长脉宽1064 nm Nd：YAG激光进行每周1次、共10~12次的治疗，随访至初次治疗后的48周，观察疗效及不良反应。结果所有病人随访至48周，总体临床有效率为72.5%。Ⅱ组的临床有效率和真菌学治愈率均高于Ⅰ组，差异有统计学意义（P〈0.05）。不同SCIO亚组之间的临床有效率无统计学差异（P〉0.05）。第2~4趾甲亚组的临床有效率优于第1、第5趾甲亚组，差异有统计学意义（P〈0.05）；所有患者无明显不良反应。结论长脉宽1064 nm Nd：YAG激光是一种安全微创有效的治疗甲真菌病的方法，可在临床推广使用。
Objective To evaluate the efficacy and safety of long pulse 1064 nm Nd：YAG laser therapy in the treatment of onychomycosis of the toenails. Methods A total of 104 patients with onychomycosis （461 toenails） were divided by age into≥60 years group and 〈60 years group, and each group was further divided into subgroups according to Scoring Clinical Index of Onychomycosis （SCIO） scoring and the location of the compromised toenails. All the toenails were treated with 10 to12 sessions of long pulse 1064 nm Nd：YAG laser therapy at the interval of 1 week. All the patients were followed up for 48 weeks after the initial treatment to assess the clinical efficacy and adverse reactions. Results The overall clinical response rate in these patients was 72.5%by the end of the 48-week follow-up. In patients aged〈60 years, the clinical response rate and mycological cure rate were significantly higher than the rates in patients aged ≥60 years （P〈0.05）. No significant differences were observed in the response rates between different SCIO subgroups （P〉0.05）; the 2nd to 4th toenails showed better outcomes after the therapy than the 1st and 5th toenails （P〈0.05）. No adverse reactions related with the therapy were recorded in these patients. Conclusion Long pulse 1064 nm Nd：YAG laser is an effective and safe approach for treatment of onychomycosis of the toenails.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2016年第5期693-696,共4页
Journal of Southern Medical University
基金
广东省科技计划项目(2011B031800224)
关键词
趾甲
甲真菌病
激光治疗
toenails
onychomycosis
laser therapy
