摘要
目的探讨多发性骨髓瘤（MM）临床特征与预后的关系。方法回顾性分析2010年1月~2015年5月本院初诊的53例MM患者的临床特点与实验室指标。采用SPSS 17.0软件进行数据统计及分析,通过单因素及多因素分析,探讨其预后影响因素。结果单因素分析显示,年龄、血红蛋白、血清钙、白蛋白、β_2微球蛋白（β_2-MG）、乳酸脱氢酶（LDH）、血肌酐水平为MM预后的相关因素。COX多因素分析显示,年龄、血清β_2-MG是MM的独立预后因素。ISS分期中,Ⅰ、Ⅱ、Ⅲ期患者的中位生存期比较,差异有统计学意义（P=0.000）。DS分期中,Ⅰ、Ⅱ、Ⅲ期患者的中位生存期比较,差异无统计学意义（P=0.917）。结论高龄、高血清β_2-MG MM患者的预后较差,ISS分期更适用于预后评估。
Objective To explore the relationship between clinical feature and prognosis of multiple myeloma（MM）.Methods The clinical characteristics and laboratory index of 53 patients with diagnosis of MM in our hospital from January 2010 to May 2015 were reviewed.SPSS 17.0 software was used for data statistics and analysis.Through univariate and multivariate analysis,the prognostic factors were explored. Results Univariate analysis showed that age,hemoglobin,serum calcium,albumin,β_2-microglobulin（β_2-MG）,lactate dehydrogenase（LDH） and serum creatinine were related factors in MM prognosis.Multivariate analysis showed that age and β_2-MG were independent prognostic factors for MM.There was significant difference in median survival time among the grade Ⅰ,Ⅱ,Ⅲ according to ISS staging（P=0.000）.There was no significant difference in median survival time among the grade Ⅰ,Ⅱ,Ⅲ according to DS staging（P=0.917）. Conclusion High level of β_2-MG and old age are correlated to poor prognosis.ISS staging would be more suitable for the evaluation of prognosis.
出处
《中国当代医药》
2016年第11期39-41,共3页
China Modern Medicine
基金
上海市宝山区卫生青年医学人才培养计划资助项目(bswsyq-2015-A07)
关键词
多发性骨髓瘤
临床特征
预后因素
Multiple myeloma
Clinical feature
Prognostic factor
