摘要
目的探讨血清人腺激肽释放酶2(hK2)的检测对于前列腺癌(PCa)患者早期诊断、预后判断和治疗手段的临床价值。方法选取2015年1～12月期间于广州医科大学附属肿瘤医院就诊的25例PCa患者和25例前列腺增生(BPH)患者及25例健康男性作为研究对象,通过酶联免疫吸附试验(ELISA)、放射免疫分析法(RIA)对hK2和前列腺特异性抗原(PSA)水平进行检测。另随机选取进行过根治性前列腺全切术的PCa组患者12例,检测并分析其手术前后hK2水平。该文所得数据采用统计学软件SPSS21.0建模处理。结果PCa组、BPH组和健康组的hK2水平分别为(75.5±24.5)ng/L、(23.3±5.8)ng/L和(22.2±3.56)ng/L,PCa组明显高于BPH组和健康组,差异均具有统计学意义(P<0.05);hK2检测PCa的特异度、准确度分别为89%和78%,25例PCa患者术后的hK2水平[(34.4±10.5)ng/L]与术前[(80.2±24.5)ng/L]相比较显著下降,差异有统计学意义(P<0.05)。结论 hK2诊断PCa患者能有效提高其检测特异度,减少患者不必要的活检率,为患者的早期临床检测、预后判断和治疗提供了新的方向,前景值得进一步挖掘。
Objective To study the clinical value of human kallikrein 2detection on the early diagnosis,prognosis and therapeutic means of patients with prostate cancer.Methods 25 patients with prostate cancer and 25 patients with benign prostatic hyperplasia who were treated in affiliated hospital of Guangzhou Medical University between January 2015 and December 2015 were selected as research objects.Their human kallikrein 2and prostate specific antigen level were detected by ELISA and RIA.25 cases of prostatic cancer after operation of our hospital in synchronization were randomly selected as research objects and their human kallikrein 2level was detected and analysed.All the data was modeling processed by SPSS21.0.Results Human kallikrein 2level of PCa group,BPH group and healthy group was（75.5±24.5）ng/L,（23.3±5.8）ng/L and（22.2±3.56）ng/L respectively,which of PCa group was higher than that of BPH group and healthy group.The difference had statistical significance（P〈0.05）.The specific and accuracy of hK2 detecting PCa was 89% and 78%.Compared with before operation[（80.2±24.5）ng/L],hK2 level of 25 patients with prostate cancer[（34.4±10.5）ng/L]significantly decreased and the difference had statistical significance（P〈0.05）.Conclusion On diagnosing prostate cancer,human kallikrein 2can improve specific detection,reduce unnecessary detected rate and provide the new direction for early clinical detection,prognosis and therapy.It deserves further promotion.
出处
《国际检验医学杂志》
CAS
2016年第9期1186-1187,共2页
International Journal of Laboratory Medicine
