摘要
目的系统评价鸦胆子油联合放疗治疗食管癌的有效性及安全性,为临床研究及临床实践提供参考。方法计算机检索The Cochrane Library,PubMed,Embase,Web of Science,中国生物医学文献服务系统（CBM）,中国知网（CNKI）,维普（VIP）和万方（Wan Fang）数据库,同时辅助其他检索,收集所有关于鸦胆子油联合放疗治疗食管癌随机对照试验（RCT）。参考Cochrane质量评价标准进行质量评价,并利用STATA version 12.0软件进行统计学分析。结果共纳入16个RCT,Meta分析结果显示,近期疗效：完全缓解（RR=1.40,95%CI：1.24-1.58,P〈0.01）、总有效率（RR=1.09,95%CI：1.03-1.16,P=0.003）优于对照组;远期疗效：1年生存期（RR=1.38,95%CI：1.17-1.61,P=0.000）、2年生存期（RR=1.64,95%CI：1.23-2.17,P=0.001）、3年生存期（RR=1.88,95%CI：1.31-2.69,P=0.001）、5年生存期（RR=3.00,95%CI：1.02-8.80,P=0.045）差异均有统计学意义;安全指标方面差异均无统计学意义（P〉0.05）。结论鸦胆子油联合放疗治疗食管癌,近期疗效及1、2、3、5年生存率均优于对照组,并且不增加放疗不良反应,值得临床推广使用。
Objective To evaluate a systematicevaluation of effectiveness and safety of oleum fructus bruceae combined with radiotherapy in the treatment of esophageal cancer,and provide reference for clinical research and clinical practice.Methods We searched Cochrane Library,PubMed,Embase,Web of Science,CBM,CNKI,VIP and Wan Fang database on line,as well as other auxiliary retrieval,and collected all of oleum fructus bruceae combined with radiotherapy in treatment of esophageal carcinoma in RCTs.The quality of study was evaluated with Cochrane quality standards,and statistical analysis was performed using STATA version 12.0software.Results A total of 16 RCTs were enrolled in the study.In these RCTs,the complete remission（CR）and total effective rate（ORR）were better than those of the control group（RR=1.40,95%CI：1.24-1.58,P〈0.01）,（RR=1.09,95%CI：1.03-1.16,P=0.003）;long term effect：the 1year（RR=1.38,95%CI：1.17-1.61,P=0.000）,2years（RR=1.64,95%CI：1.23-2.17,P=0.001）,3years（RR=1.88,95%CI：1.31-2.69,P=0.001）and 5years（RR=3.00,95%CI：1.02-8.80,P=0.045）survival period results showed statistically significant difference;we compared radiation esophagitis,bone marrow suppression,gastrointestinal reactions,and these safety indicators showed no significant difference（P〈0.05）.Conclusion Both in shortterm and 1,2,3,5years survival,oleum fructus bruceae combined with radiotherapy in the treatment of esophageal cancer is superior than control group.Meanwhile,there was no increase in adverse effects induced by radiotherapy.Therefore,the mode of combined treatment is beneficial to clinical.
出处
《重庆医学》
CAS
北大核心
2016年第14期1937-1941,共5页
Chongqing medicine
基金
贵州省科学技术基金资助项目(黔科合J字[2014]2186)
关键词
鸦胆子
随机对照试验
食管肿瘤
放射治疗
META分析
brucea javanica
randomized controlled trial
esophageal neoplasms
radiotherapy
Meta-analysis
