摘要
目的:分析手术中大量失血和急性髓系白血病患者血小板减少与凝血功能的关系。方法:选择本院手术大出血患者(手术大出血组)、急性髓系白血病患者(急性髓系白血病组)各30例,体检健康人群30例为健康对照组,平行检测三组血小板计数(PLT)、血浆纤维蛋白原(FIB)含量及凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)和国际标准化比值(INR),比较各指标组间差异,分析各组PLT与凝血指标的相关性。结果:手术大出血组、急性髓系白血病组PLT明显低于健康对照组(P<0.01),急性髓系白血病组更低(P<0.01);急性髓系白血病组PT、APTT较健康对照组显著延长(P<0.01),手术大出血组较急性髓系白血病组PT、APTT延长,INR升高(P<0.01);手术大出血组FIB水平较健康对照组显著降低(P<0.01)。相关性分析表明,急性髓系白血病患者PLT与FIB水平呈负相关(r=-0.374,P<0.05)。结论:术中大量出血患者PLT高于急性髓系白血病患者,但凝血功能较差,出血风险较大。
Objective：To analysis effect of a large amount of blood loss in operation with thrombocytopenia caused acute myeloid leukemia on blood coagulation function .Method：90 cases of patients in our hospital were clas‐sified in surgery massive bleeding group（n=30） ,acute myeloid leukemia group（n=30）and normal control group（n=30） .The content of PLT ,FIB in the blood and the time of PT ,APTT ,INR were detected ,differences between groups of indicators ,and the correlation between each PLT and other indicators were analyzed .Results：The PLT count of surgical massive bleeding group and the acute myeloid leukemia group were significantly lower than the nor‐mal control group（P〈0 .01） ,acute myeloid leukemia group was the lowest .The PT ,APTT in the acute myeloid leukemia groups compared with normal control group were significantly extended （P〈0 .01） ,the most prolonged was surgery massive bleeding group（P〈0 .01） .Another ,surgical bleeding group FIB level was significantly lower than normal control group（P〈0 .01） .The correlation analysis showed that the acute myeloid leukemia group PLT and FIB levels were a negative correlation .Conclusion：The PLT count in surgery massive bleeding patients is higher than in patients with acute myeloid leukemia patients ,but the blood coagulation function is poorer ,there is a greater risk of bleeding .
出处
《微循环学杂志》
2016年第2期18-20,共3页
Chinese Journal of Microcirculation
关键词
手术大出血
急性髓系白血病
血小板计数
凝血功能
Surgical bleeding
Acute myeloid leukemia
Platelet count
Coagulation function
