摘要
目的探讨原发性癫痫合并阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者的临床特点。方法回顾性分析2007-06-2014-06在我院确诊的16例原发性癫痫合并OSAHS患者的临床资料（包括病史、多导睡眠脑电图及治疗随访）。结果癫痫形式表现为全面强直阵挛发作13例,部分性发作3例,其中夜间发作11例,白天发作5例;多导睡眠脑电图（polysomnography,PSG）显示均为阻塞性睡眠呼吸暂停低通气综合征（OSAHS）,其中重度9例,中度4例,轻度3例。所有患者经抗癫痫药物治疗及OSAHS的指导性治疗。其中4例癫痫伴重度OSAHS经单纯药物治疗仍反复发作,联合丙戊酸钠和经鼻持续气道正压通气（CPAP）治疗,随访0.5~3a,发作频率减少3例,发作停止1例。结论原发性癫痫合并OSAHS一般以中老年男性多见,癫痫类型以夜间全面强直阵挛性发作为主,对于单纯抗癫痫药物治疗不佳者,药物联合CPAP治疗可取得明显效果。
Objective To investigate the clinical characteristics of obstructive sleep apnea hypopnea syndrome（OSAHS） in patients with epilepsy. Methods Clinical data（mainly including history, polysomnography, therapy and follow-up visits） of 16 idiopathic epilepsy cases with OSAHS admitted to our hospital from June 2007 to June 2014 were analyzed retrospective- ly. Results Of all the 16 cases, generalized tonic-clonic seizures occurred in 13 cases and partial seizures in 3 cases, 11 cases hap- pened at night and 5 cases happened in the daytime. Of all patients diagnosed as OSAHS by the monitor of polysomnography, there were 4 severe OSAHS,4 moderate OSAHS and 3 mild OSAHS. Patients with severe OSAHS still repeated seizures after the treatment of simple antiepileptic drugs, but the frequency of seizures decreased in 3 cases and the seizure ceased in 1 case for six months to 3 years follow-up when patients were treated by sodium volproate and continuous positive airway pressure（CPAP）. Conclusion OSAHS with epilepsy is much common in middle-aged males. And the main type of seizure is generalized tonic-clonic seizure which usually occurs at night. For patients with worse effect treated by single antiepileptic drug, the com- bined treatment of antiepileptic drugs and CPAP is more effective.
出处
《中国实用神经疾病杂志》
2016年第6期4-5,共2页
Chinese Journal of Practical Nervous Diseases
基金
国家临床重点专科建设项目(卫办医政函[2012]649号)
