摘要
膜性肾病为成人常见的肾病综合征病因,根据继发性因素的有无可分为特发性膜性肾病与继发性膜性肾病。特发性膜性肾病因其无明确继发因素、病情迁延、预后差异较大等临床特点而备受关注。特发性膜性肾病属于足细胞病,而特异性抗体识别足细胞抗原并活化补体,这在特发性膜性肾病的发病中起着重要作用。因此,对于特发性膜性肾病发病机制的研究一直以来都是研究的热点。
Membranous nephropathy is a common cause of adult nephrotic syndrome, based on the exist- ence of secondary factors it is divided into idiopathic and secondary membranous nephropathy. Idiopathic membranous nephropathy has drawn much attention because of the clinical features of no clear secondary fac- tom, protracted illness and largely different prognosis. Idiopathic membranous nephropathy belongs to foot cell disease, and foot cell antigen-specific antibody recognizes and activates complement, which plays an important role in the pathogenesis of idiopathic membranous nephropathy. Thus, study on the pathogenesis of idiopathic membranous nephropathy has always been a hot research spot.
出处
《医学综述》
2016年第9期1676-1679,共4页
Medical Recapitulate
关键词
特发性膜性肾病
发病机制
补体
补体系统
补体激活
Idiopathic membranous nephropathy
Pathogenesis
Complement
Complement system
Complement activation
