摘要
目的观察双歧三联活菌联合美沙拉嗪治疗溃疡性结肠炎(UC)的临床疗效。方法选取收治的UC患者102例,随机分为对照组和观察组各51例,观察组给予美沙拉嗪及双歧三联活菌口服,对照组只给予美沙拉嗪口服。观察两组的疗效及治疗前后的炎性细胞因子和凝血参数等变化。结果观察组治疗总有效率达96.07%,而对照组仅为82.35%,两组比较差异具有统计学意义(P<0.05);观察组治疗后TNF-α、IL-6、IL-1、IL-8均低于对照组,Fib、MPV指标值均高于对照组,差异均具有统计学意义(P<0.05)。结论双歧三联活菌联合美联合美沙拉嗪治疗溃疡性结肠炎的临床疗效优于单纯使用美沙拉嗪,具有临床运用价值。
Objective To observe the clinical efficacy of the combination of the triple viable bacteria and Mesalamine the treatment of ulcerative colitis（UC）. Methods 102 cases of UC were selected and randomly divided into control group and observation group, 51 cases in each group.The observation group was treated with the combination of the United States and the United States. The control group was given only the oral administration of the United States. Observe the curative effect of the two groups and the changes of inflammatory cytokines and coagulation parameters before and after treatment. Results Observed in the treatment group, the total effective rate was 96.07%, while the control group only was 82.35%, the difference between the two groups has statistical significance（P〈0.05）; after treatment in observation group of TNF-a, IL-6, IL-1, IL-8 were lower than the control group, FIB, MPV index values were higher than those in the control group, the differences were statistically significant（P〈0.05）. Conclusions The clinical effect of combined treatment of the combination of the triple viable bacteria and the United States combined with the United States and the United States in the treatment of ulcerative colitis is better than that of the simple use of the United States and the United States, which has the value of clinical application.
出处
《现代诊断与治疗》
CAS
2016年第4期593-595,共3页
Modern Diagnosis and Treatment
