摘要
目的探讨红花注射液对高血压患者脉搏波传导速度及肾素-血管紧张素-醛固酮系统(RAAS)的影响。方法将128例高血压患者随机分为对照组和治疗组,每组64例;对照组采用常规抗高血压药物治疗,治疗组在此基础上加用红花注射液静脉滴注,疗程28 d。观察两组临床疗效及治疗前后脉搏波传导速度(ba PWV、cf PWV、fa PWV)及RAAS指标(ALD、Ang-Ⅰ、Ang-Ⅱ、PRA)变化情况。结果 1治疗组临床总有效率为89.06%,对照组为70.31%;治疗组临床疗效优于对照组(P<0.05);2治疗后,两组ba PWV、cf PWV、fa PWV值均较治疗前明显降低(P<0.05,P<0.01),且治疗组低于对照组(P<0.05)。3治疗后,两组血清Ang-Ⅰ、Ang-Ⅱ、ALD、PRA值均较治疗前明显降低(P<0.05,P<0.01),且治疗组低于对照组(P<0.05)。结论红花注射液可以明显降低PWV及RAAS指标发挥治疗高血压的作用。
Objective To observe the influence of Safflower Injection on pulse wave velocity （PWV） and RAAS in patients with hypertension. Methods One hundred and twenty-eight subjects were randomized into control group and treatment group, 64 cases in each group. The control group was given conventional antihypertensive treatment, and the treatment group was given intravenous injection of Safflower Injection besides the antihypertensive treatment, with the course of 28 days. The clinical efficacy and the indicators related to pulse wave velocity（ baPWV, cfPWV, faPWV） and RAAS （ALD, Ang-I, Ang-II, PRA） before and after treatment were observed in both groups. Results （~）The total effective rate was 70.31% in the control group and 89.06% in the treatment group, with better efficacy in the treatment group than in the control group （P 〈 0.05 ）. ~）Afler treatment, the baPWV, cfPWV and faPWV were reduced in both groups （P 〈 0.05, P 〈 0.01 ） , with more significant reduction in the treatment group than in the control group（ P 〈 0.05 ）. （~）After treatment, the levels of ALD, Ang- ] , Ang-ff and PRA were decreased in both groups（P 〈0.05, P 〈0.01 ）, with more significant decrease in the treatment group than in the control group（P 〈0.05）. Conclusion Safflower Injection helps fighting hypertension by reducing the indicators related to PWV and RAAS in patients with hypertension.
出处
《上海中医药杂志》
2016年第5期45-47,共3页
Shanghai Journal of Traditional Chinese Medicine
