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肝癌复发转移的分子机制与病理学评估策略 被引量:15

Molecular mechanism and pathological evaluation strategies for recurrence and metastasis of liver cancer
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摘要 肝细胞癌(HCC)极强的侵袭和转移特征,既是导致HCC术后高复发率和远期疗效差的重要病理学机制,也是临床制订个体化抗转移复发方案的重要病理学依据。现简要介绍近年来对肿瘤侵袭一转移级联反应过程中重要分子事件的认识,包括转移性龛环境的形成机制、分子病理学评估方法和规范化病理学诊断。 The strong invasiveness and metastasis of hepatocellular carcinoma (HCC) are not only the important pathological mechanisms of high recurrence rate and poor long-term outcome, but also the important pathological basis for developing individualized regimens to control metastasis and recurrence in clinical practice. This article introduces the important molecular events in invasion-metastasis cascade discovered in recent years, including the formation mechanism of metastatic niches, methods for molecular pathological evaluation, and standardized pathological diagnosis.
作者 丛文铭
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2016年第5期324-326,共3页 Chinese Journal of Hepatology
基金 国家自然科学基金(81272662、81472278) 国家自然科学创新研究群体科学基金(1521091)
关键词 肝细胞 肿瘤转移 病理学 诊断 复发 机制 Carcinoma, hepatocellular Neoplasm metastasis Pathology Diagnosis Recurrence Mechanism
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